Table 1. Distribution of non-blast cell subsets in the BM of children with BCP-ALL at diagnosis according to the presence vs. absence of altered immunophenotypes on residual maturing and mature BM neutrophils.
| Cell subsets | BCP-ALL with normal neutrophil phenotypes | BCP-ALL with altered neutrophil phenotypes | p-value |
|---|---|---|---|
| % of maturing neutrophils | 28 (5–55) |
19 (2–64) |
p = 0.004 |
| % of monocytes | 0.92 (0.15–6.7) |
1.04 (< 0.1–15) |
ns |
| % of eosinophils | 0.73 (0.07–8.1) |
0.81 (< 0.1–5.5) |
ns |
| % of basophils | 0.18 (< 0.1–1.6) |
0.21 (< 0.1–6.5) |
ns |
| % of NRBC | 11.1 (1–32) |
9.12 (0.3–67) |
ns |
| % of lymphocytes | 37 (20–84) |
51 (8.8–92) |
p = 0.04 |
| % of T cells | 29 (15–75) |
35 (5–75) |
ns |
| % of NK cells | 2.2 (< 0.1–7.9) |
2.6 (< 0.1–27) |
ns |
| % of mature B cells | 7.1 (< 0.1–22) |
8.8 (< 0.1–39) |
p = 0.03 |
| % of CD34+ myeloid precursors | 0.3 (< 0.1–1.3) |
0.6 (< 0.1–3) |
p = 0.03 |
| % of CD34+/MPO+ neutrophil precursors from all CD34+ HPC | 8 (< 0.1–100) |
< 0.01 (< 0.1–100) |
ns |
| % of CD34+/CD7+ precursors from all CD34+ HPC | < 0.01 (< 0.1 – 13) |
< 0.01 (< 0.1–88) |
ns |
Results expressed as median (range). BCP-ALL, B-cell precursor acute lymphoblastic leukemia; BM, bone marrow; NRBC, nucleated red blood cells; HPC, hematopoietic progenitor cells.