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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1990 Dec;43(12):1032–1033. doi: 10.1136/jcp.43.12.1032

Potential role of IgG avidity for diagnosing toxoplasmosis.

D H Joynson 1, R A Payne 1, B K Rawal 1
PMCID: PMC502981  PMID: 2132560

Abstract

Sera from 20 cases of toxoplasmic lymphadenopathy were examined by an enzyme linked immunosorbent assay toxoplasma IgG avidity (ELISA) at two laboratories. The results obtained were largely in agreement and showed that sera from patients with acute infection had low avidity IgG (30% or less), whereas sera from patients with chronic infection had high avidity IgG (40% or more). It is suggested that this type of assay could have a useful complementary role in antenatal testing for toxoplasmosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown S. E., Howard C. R., Zuckerman A. J., Steward M. W. Affinity of antibody responses in man to hepatitis B vaccine determined with synthetic peptides. Lancet. 1984 Jul 28;2(8396):184–187. doi: 10.1016/s0140-6736(84)90479-3. [DOI] [PubMed] [Google Scholar]
  2. Francis J. M., Payne R. A., Joynson D. H. Rapid indirect enzyme linked immunosorbent assay (ELISA) for detecting antitoxoplasma IgG: comparison with dye test. J Clin Pathol. 1988 Jul;41(7):802–805. doi: 10.1136/jcp.41.7.802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hedman K., Lappalainen M., Seppäiä I., Mäkelä O. Recent primary toxoplasma infection indicated by a low avidity of specific IgG. J Infect Dis. 1989 Apr;159(4):736–740. doi: 10.1093/infdis/159.4.736. [DOI] [PubMed] [Google Scholar]
  4. Inouye S., Hasegawa A., Matsuno S., Katow S. Changes in antibody avidity after virus infections: detection by an immunosorbent assay in which a mild protein-denaturing agent is employed. J Clin Microbiol. 1984 Sep;20(3):525–529. doi: 10.1128/jcm.20.3.525-529.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Joynson D. H., Payne R. Screening for toxoplasma in pregnancy. Lancet. 1988 Oct 1;2(8614):795–796. doi: 10.1016/s0140-6736(88)92443-9. [DOI] [PubMed] [Google Scholar]
  6. Morgan-Capner P., Thomas H. I. Serological distinction between primary rubella and reinfection. Lancet. 1988 Jun 18;1(8599):1397–1397. doi: 10.1016/s0140-6736(88)92209-x. [DOI] [PubMed] [Google Scholar]
  7. Payne R. A., Joynson D. H., Balfour A. H., Harford J. P., Fleck D. G., Mythen M., Saunders R. J. Public Health Laboratory Service enzyme linked immunosorbent assay for detecting Toxoplasma specific IgM antibody. J Clin Pathol. 1987 Mar;40(3):276–281. doi: 10.1136/jcp.40.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rousseau S., Hedman K. Rubella infection and reinfection distinguished by avidity of IgG. Lancet. 1988 May 14;1(8594):1108–1109. doi: 10.1016/s0140-6736(88)91926-5. [DOI] [PubMed] [Google Scholar]
  9. Wreghitt T. G., Gray J. J., Aloyisus S., Contreras M., Barbara J. A. Antibody avidity test for recent infection with hepatitis C virus. Lancet. 1990 Mar 31;335(8692):789–789. doi: 10.1016/0140-6736(90)90902-h. [DOI] [PubMed] [Google Scholar]

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