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. 1994 Nov;47(11):1035–1037. doi: 10.1136/jcp.47.11.1035

Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract.

T E Ind 1, R K Iles 1, P G Carter 1, D G Lowe 1, J H Shepherd 1, C N Hudson 1, T Chard 1
PMCID: PMC503069  PMID: 7829680

Abstract

AIM--To investigate serum placental-type alkaline phosphatase (PLAP-type) activities in women with squamous and glandular malignancies of the reproductive tract using an immunoradiometric assay. METHODS--PLAP-type immunoreactivity was measured in 180 women with non-ovarian malignancies of the reproductive tract and the values were compared with those from 334 controls. The cases comprised 18 vulval, nine vaginal, 103 cervical, 46 endometrial, and five fallopian tube cancers. RESULTS--Serum PLAP-type activities were no different from controls in patients with squamous cell tumours. Women with adenocarcinoma of the cervix, endometrium, and fallopian tube had increased values: women with endometrial cancer had a median value nearly four times greater than that of controls. There was no direct correlation between PLAP-type activities and stage of disease in patients with endometrial cancer, but values reverted to normal after treatment. CONCLUSIONS--Serum PLAP-type measurements are of no value in the management of patients with squamous cell tumours of the female reproductive tract. Raised activities can, however, be found in glandular tumours, in particular endometrial cancer where serum PLAP-type measurements may be of value in predicting remission.

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Selected References

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  1. Benham F., Cottell D. C., Franks L. M., Wilson P. D. Alkaline phosphatase activity in human bladder tumor cell lines. J Histochem Cytochem. 1977 Apr;25(4):266–274. doi: 10.1177/25.4.870558. [DOI] [PubMed] [Google Scholar]
  2. Cadeau B. J., Blackstein M. E., Malkin A. Increased incidence of placenta-like alkaline phosphatase activity in breast and genitourinary cancer. Cancer Res. 1974 Apr;34(4):729–732. [PubMed] [Google Scholar]
  3. Chatzaki E., Gallagher C. J., Iles R. K., Ind T. E., Nouri A. M., Bax C. M., Grudzinskas J. G. Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium. Br J Cancer. 1994 Jun;69(6):1010–1014. doi: 10.1038/bjc.1994.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies J. O., Davies E. R., Howe K., Jackson P., Pitcher E., Randle B., Sadowski C., Stirrat G. M., Sunderland C. A. Practical applications of a monoclonal antibody (NDOG2) against placental alkaline phosphatase in ovarian cancer. J R Soc Med. 1985 Nov;78(11):899–905. doi: 10.1177/014107688507801104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. De Broe M. E., Pollet D. E. Multicenter evaluation of human placental alkaline phosphatase as a possible tumor-associated antigen in serum. Clin Chem. 1988 Oct;34(10):1995–1999. [PubMed] [Google Scholar]
  6. Doellgast G. J., Homesley H. D. Placental-type alkaline phosphatase in ovarian cancer fluids and tissues. Obstet Gynecol. 1984 Mar;63(3):324–329. [PubMed] [Google Scholar]
  7. Fishman W. H., Inglis N. R., Green S., Anstiss C. L., Gosh N. K., Reif A. E., Rustigian R., Krant M. J., Stolbach L. L. Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer. Nature. 1968 Aug 17;219(5155):697–699. doi: 10.1038/219697a0. [DOI] [PubMed] [Google Scholar]
  8. Fishman W. H., Inglis N. R., Vaitukaitis J., Stolbach L. L. Regan isoenzyme and human chorionic gonadotropin in ovarian cancer. Natl Cancer Inst Monogr. 1975 Oct;42:63–73. [PubMed] [Google Scholar]
  9. Fisken J., Leonard R. C., Shaw G., Bowman A., Roulston J. E. Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer. J Clin Pathol. 1989 Jan;42(1):40–45. doi: 10.1136/jcp.42.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haije W. G., van Driel J., van der Burg M. E. Catalytic and immunologic activities of placental-like alkaline phosphatase in clinical studies. The value of PLAP in follow-up of ovarian cancer. Clin Chim Acta. 1987 Jun 15;165(2-3):165–175. doi: 10.1016/0009-8981(87)90160-4. [DOI] [PubMed] [Google Scholar]
  11. Horwich A., Tucker D. F., Peckham M. J. Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay. Br J Cancer. 1985 May;51(5):625–629. doi: 10.1038/bjc.1985.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hoylaerts M. F., Manes T., Millán J. L. Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase. Biochem J. 1992 Aug 15;286(Pt 1):23–30. doi: 10.1042/bj2860023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Iles R. K., Ind T. E., Chard T. Production of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro. Br J Cancer. 1994 Feb;69(2):274–278. doi: 10.1038/bjc.1994.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ind T. E., Iles R. K., Chard T. Low serum levels of placental and placental-like alkaline phosphatase isoenzymes in women with blood groups A and AB. Ann Clin Biochem. 1994 Jan;31(Pt 1):89–90. doi: 10.1177/000456329403100116. [DOI] [PubMed] [Google Scholar]
  15. Ind T. E., Iles R. K., Wathen N. C., Murugan P., Campbell J., Macintosh M., Chard T. Low levels of amniotic fluid placental alkaline phosphatase in Down's syndrome. Br J Obstet Gynaecol. 1993 Sep;100(9):847–849. doi: 10.1111/j.1471-0528.1993.tb14312.x. [DOI] [PubMed] [Google Scholar]
  16. Kellen J. A., Bush R. S., Malkin A. Placenta-like alkaline phosphatase in gynecological cancers. Cancer Res. 1976 Jan;36(1):269–271. [PubMed] [Google Scholar]
  17. Kenemans P., Yedema C. A., Hilgers J. H., Massuger L. F., Verheijen R. H., Thomas C. M., Poels L. G. Clinical applications of monoclonal antibodies against ovarian cancer-associated antigens. Eur J Obstet Gynecol Reprod Biol. 1988 Nov;29(3):207–218. doi: 10.1016/s0028-2243(88)80025-x. [DOI] [PubMed] [Google Scholar]
  18. Lange P. H., Millan J. L., Stigbrand T., Vessella R. L., Ruoslahti E., Fishman W. H. Placental alkaline phosphatase as a tumor marker for seminoma. Cancer Res. 1982 Aug;42(8):3244–3247. [PubMed] [Google Scholar]
  19. Mano H., Furuhashi Y., Morikawa Y., Hattori S. E., Goto S., Tomoda Y. Radioimmunoassay of placental alkaline phosphatase in ovarian cancer sera and tissues. Obstet Gynecol. 1986 Dec;68(6):759–764. [PubMed] [Google Scholar]
  20. Maslow W. C., Muensch H. A., Azama F., Schneider A. S. Sensitive fluorometry of heat-stable alkaline phosphatase (Regan enzyme) activity in serum from smokers and nonsmokers. Clin Chem. 1983 Feb;29(2):260–263. [PubMed] [Google Scholar]
  21. McDicken I. W., McLaughlin P. J., Tromans P. M., Luesley D. M., Johnson P. M. Detection of placental-type alkaline phosphatase in ovarian cancer. Br J Cancer. 1985 Jul;52(1):59–64. doi: 10.1038/bjc.1985.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. McLaughlin P. J., Gee H., Johnson P. M. Placental-type alkaline phosphatase in pregnancy and malignancy plasma: specific estimation using a monoclonal antibody in a solid phase enzyme immunoassay. Clin Chim Acta. 1983 May 30;130(2):199–209. doi: 10.1016/0009-8981(83)90117-1. [DOI] [PubMed] [Google Scholar]
  23. McLaughlin P. J., Twist A. M., Evans C. C., Johnson P. M. Serum placental type alkaline phosphatase in cigarette smokers. J Clin Pathol. 1984 Jul;37(7):826–828. doi: 10.1136/jcp.37.7.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Muensch H. A., Maslow W. C., Azama F., Bertrand M., Dewhurst P., Hartman B. Placental-like alkaline phosphatase. Re-evaluation of the tumor marker with exclusion of smokers. Cancer. 1986 Oct 15;58(8):1689–1694. doi: 10.1002/1097-0142(19861015)58:8<1689::aid-cncr2820580818>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  25. Nouwen E. J., Pollet D. E., Schelstraete J. B., Eerdekens M. W., Hänsch C., Van de Voorde A., De Broe M. E. Human placental alkaline phosphatase in benign and malignant ovarian neoplasia. Cancer Res. 1985 Feb;45(2):892–902. [PubMed] [Google Scholar]
  26. Nozawa S., Udagawa Y., Ohkura H., Negishi Y., Akiya K., Inaba N., Takamizawa H., Kimura E., Terashima Y. Serum placental alkaline phosphatase (PLAP) in gynecologic malignancies--with special reference to the combination of PLAP and CA54/61 assay. Clin Chim Acta. 1990 Jan 15;186(2):275–284. doi: 10.1016/0009-8981(90)90045-t. [DOI] [PubMed] [Google Scholar]
  27. Tholander B., Taube A., Lindgren A., Sjöberg O., Stendahl U., Tamsen L. Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase in patients with ovarian carcinoma: influence of histological type, grade of differentiation, and clinical stage of disease. Gynecol Oncol. 1990 Oct;39(1):26–33. doi: 10.1016/0090-8258(90)90394-z. [DOI] [PubMed] [Google Scholar]
  28. Tonik S. E., Ortmeyer A. E., Shindelman J. E., Sussman H. H. Elevation of serum placental alkaline phosphatase levels in cigarette smokers. Int J Cancer. 1983 Jan 15;31(1):51–53. doi: 10.1002/ijc.2910310109. [DOI] [PubMed] [Google Scholar]
  29. Tucker D. F., Oliver R. T., Travers P., Bodmer W. F. Serum marker potential of placental alkaline phosphatase-like activity in testicular germ cell tumours evaluated by H17E2 monoclonal antibody assay. Br J Cancer. 1985 May;51(5):631–639. doi: 10.1038/bjc.1985.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Vergote I. B., Abeler V. M., Børmer O. P., Stigbrand T., Tropé C., Nustad K. CA125 and placental alkaline phosphatase as serum tumor markers in epithelial ovarian carcinoma. Tumour Biol. 1992;13(3):168–174. doi: 10.1159/000217761. [DOI] [PubMed] [Google Scholar]
  31. Vergote I., Onsrud M., Nustad K. Placental alkaline phosphatase as a tumor marker in ovarian cancer. Obstet Gynecol. 1987 Feb;69(2):228–232. [PubMed] [Google Scholar]

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