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. 2016 Jul 20;38(9):830–838. doi: 10.1002/bies.201600100

Figure 2.

Figure 2

A general outline of mammalian NMD including (A) EJC‐dependent mechanism and (B) EJC‐independent mechanism. Note that the exact composition of the NMD machinery may differ depending on eukaryotic group. Abbreviations: eIF, eukaryotic initiation factor; EJC, exon junction complex; PABP, poly(A) binding protein; PTC, premature termination codon.