Figure 1.

Changes in brain activations over time with lorcaserin. Shown are brain activations for placebo > lorcaserin to highly desirable compared with less desirable food images in the fasting state after 1 week (A), to all food compared with nonfood images in the fed state after 4 weeks (B), and to highly desirable images compared with less desirable food images in the fasting state for short-term (1 week) compared with long-term (4 weeks) treatments (C). BOLD contrasts are superimposed on a T1 structural image in axial sections from z = −15 to z = 60, in neurological orientation.