Intratesticular (A) and serum (B) testosterone (T) levels in animals not pre-treated with ethane dimethanesulfonate (EDS) (HN, CP, CP+HN) were not significantly different from vehicle-treated rats (Light bars). In the EDS-treated animals, intratesticular and serum testosterone levels were markedly reduced in all groups (EDS, EDS + HN, EDS + CP, EDS + CP + HN). HN did not restore intratesticular and serum testosterone levels in the EDS-treated rats (Dark bars). There were four rats in each group.