A Cost-Utility Analysis of Lisdexamfetamine Versus Atomoxetine in the Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder and Inadequate Response to Methylphenidate

Abstract

Background

An economic analysis from the perspective of the UK National Health Service (NHS) evaluated the cost effectiveness of lisdexamfetamine dimesylate (LDX) compared with atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder who have had an inadequate response to methylphenidate.

Methods

A 1-year decision-analytic model was constructed, with the health outcomes “response”, “nonresponse”, and “unable to tolerate”. Clinical data were taken from a head-to-head, randomized controlled trial in inadequate responders to methylphenidate. Response to treatment was defined as a score of 1 (very much improved) or 2 (much improved) on the Clinical Global Impression–Improvement subscale. Tolerability was assessed by discontinuation rates owing to adverse events. Utility weights were identified via a systematic literature review. Healthcare resource use estimates were obtained via a survey of clinicians. Daily drug costs were derived from British National Formulary 2012 costs and mean doses reported in the trial. One-way and probabilistic sensitivity analyses (PSAs) were performed.

Results

The comparison of LDX with atomoxetine resulted in an estimate of an incremental cost-effectiveness ratio of £1802 per quality-adjusted life-year (QALY). The result was robust in a wide range of sensitivity analyses; results were most sensitive to changes in drug costs and efficacy. In the PSA, assuming a maximum willingness to pay of £20,000 per QALY, LDX versus atomoxetine had an 86 % probability of being cost effective. In 38 % of PSA runs, LDX was more effective and less costly than atomoxetine.

Conclusions

From the perspective of the UK NHS, LDX provides a cost-effective treatment option for children and adolescents who are inadequate responders to methylphenidate.

Electronic supplementary material

The online version of this article (doi:10.1007/s40263-016-0354-3) contains supplementary material, which is available to authorized users.

Key Points

About one-third of patients have an inadequate response to initial treatment with methylphenidate and consequently might be considered for treatment with atomoxetine or lisdexamfetamine dimesylate (LDX).

In this patient population, LDX was associated with a faster and more robust treatment response than atomoxetine, as demonstrated in a 9-week, head-to-head, randomized, double-blind, active-controlled study.

An economic analysis, conducted using data from the head-to-head trial, showed that LDX is a cost-effective treatment option compared with atomoxetine in children and adolescents who have had an inadequate response to methylphenidate.

Introduction

Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioral disorder that is estimated to affect 5.3 % of children worldwide, 5 % of European children, and 6–6.5 % of children in North America [1, 2]. The core symptoms of ADHD include inattention, impulsivity, and hyperactivity [3]. It is associated with impairment that affects not only the child but also parents and siblings, causing disturbances to family and marital functioning, and reduction in the overall quality of life [4, 5]. ADHD often persists into adulthood, causing disruptions to both professional and personal life [4] and imposes a considerable cost on the healthcare system and society. In the USA, the economic burden of ADHD in children and adolescents is estimated to be between $US38 billion and $US72 billion per year, of which healthcare cost estimates range between $US21 billion and $US44 billion [6]. A review of European-based studies of ADHD-related costs estimated annual average total costs to be between €9860 and €14,483 per patient [7]. In Europe, the annual national costs were estimated to be between €1041 and €1529 million [7], using the Netherlands as a reference country.

Management of ADHD usually includes psychotherapy and behavioral therapy, parent training, medications, or a combination of both psychotherapy and pharmacotherapy. In the UK, the stimulant methylphenidate is a recommended first-line treatment, with the nonstimulant atomoxetine considered for first-line treatment when tics, Tourette’s syndrome, anxiety disorder, stimulant misuse, or risk of stimulant diversion are present [8]. It has been estimated that as many as 25–35 % of subjects in clinical trials may have an inadequate response to initial stimulant treatment [9]. In the UK, atomoxetine is the recommended treatment option in patients who have had inadequate response or are intolerant to methylphenidate [8, 10]. Atomoxetine was found to be a cost-effective option compared with stimulant therapy (represented in the model by methylphenidate and dexamphetamine) when evaluated from the perspective of the National Health Service (NHS) in the stimulant-exposed UK population [11].

Lisdexamfetamine dimesylate (LDX) is a pro-drug; following absorption, LDX undergoes hydrolysis to dexamphetamine. LDX has been studied in several large, phase III trials in children and adolescents and has been shown to be effective in reducing the symptoms of ADHD. Three trials in children and adolescents with ADHD were placebo controlled [12–14], and one was a head-to-head study versus atomoxetine in children and adolescents with ADHD who have had an inadequate response to methylphenidate (either immediate or extended release) [15]. In the head-to-head study, the median time to first clinical response, defined as a Clinical Global Impressions–Improvement (CGI-I) score of 1 (very much improved) or 2 (much improved), 95 % confidence interval (CI) was significantly shorter for patients receiving LDX (12.0 days [8.0–16.0]) than for those receiving atomoxetine (21.0 days [15.0–23.0]) (p = 0.001) [15]. Moreover, at the completion of the 9-week study period, a greater proportion of patients achieved improved global functioning, as measured by the CGI-I [16], designed to rate severity of illness and improvement in symptom severity (103/126 patients [81.7 %] in the LDX group compared with 84/132 patients [63.6 %] in the atomoxetine group) [15]. Similarly, a greater proportion of patients receiving LDX experienced improvement in symptoms, as measured by the ADHD Rating Scale-IV, designed to reflect current symptomatology of ADHD based on Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) criteria [17] (114/126 patients [90.5 %] in the LDX group achieved response [defined as a percentage reduction from baseline in the ADHD-RS-IV total score of ≥25 %] compared with 102/133 patients [76.7 %] in the atomoxetine group) [18]. Although estimates of the time required for atomoxetine to reach its maximum effect generally range from 4 to 6 weeks [8, 19], one study suggests that it may take as long as 12 weeks [20]. The objective of the present study is to estimate the cost effectiveness of LDX compared with atomoxetine in the treatment of children and adolescents with ADHD in whom response to methylphenidate (either extended release or immediate release) is considered clinically inadequate. The results of the analysis are presented as the total costs and total quality-adjusted life-years (QALYs) for each drug, as well as the incremental costs and QALYs for LDX when compared with atomoxetine. The incremental cost-effectiveness ratio (ICER) for LDX relative to atomoxetine is also presented and evaluated against an established cost-effectiveness threshold of £20,000 per QALY [21].

Methods

A decision-tree model was developed in Microsoft^® Excel (Microsoft Corp., Redmond, WA, USA) to evaluate the cost effectiveness of LDX compared with atomoxetine from the perspective of the UK NHS. The health outcomes used in the model as the measures of benefit were “unable to tolerate”, “response”, and “nonresponse” (Fig. 1). The impact of using LDX as an alternative to atomoxetine in terms of costs and outcomes was estimated in the model by simulating the number of patients who achieved a response to treatment and those who did not. Costs and utilities corresponding to the patients’ health states were assigned to each of these patients. The target population for the analysis consisted of children and adolescents with ADHD in whom response to methylphenidate was considered clinically inadequate. An inadequate response to methylphenidate, as defined in the LDX head-to-head study versus atomoxetine [15] included, but was not limited to, one or more of the following: the presence of some residual ADHD symptoms; inadequate duration of action; variable symptom control; as well as whether, in the opinion of the investigator, the patient may benefit from an alternative to methylphenidate [15]. The base-case analysis evaluated direct medical costs and health-related quality of life associated with 1 year of treatment, including the initial 28-day drug titration period. The time horizon of 1 year was chosen to capture differences in the cost and benefits for the time period of the clinical trial, given the lack of long-term data comparing LDX and atomoxetine. The dichotomous response modelling framework and key assumptions, including the 1-year time horizon, were adapted from the health technology assessment (HTA) model used in an earlier assessment of ADHD drugs by the UK National Institute for Health and Care Excellence (NICE) [22].

Fig. 1.

Model structure. ADHD attention-deficit/hyperactivity disorder, ATX atomoxetine, LDX lisdexamfetamine dimesylate, MPH methylphenidate, NT no treatment

Model Assumptions

Patients who inadequately responded to methylphenidate entered the model when they initiated a course of treatment with either LDX or atomoxetine.

Patients who experienced intolerable side effects discontinued treatment in the middle of the titration period, i.e., after 14 days of treatment. The discontinuation of patients’ utilities and costs during the titration period (28 days) was represented by a 50/50 % mix of the responder and nonresponder utility values and a 50/50 % mix of the responder and nonresponder nondrug costs, respectively.

Patients who discontinued treatment because of intolerable side effects did not initiate additional treatment because they have failed both methylphenidate and a second-line drug. Patients who discontinued because of intolerable side effects had the same utilities and costs as nonresponders for the remainder of the 1-year model time horizon.

Patients who responded to treatment at the end of the titration period continued to receive treatment throughout the model’s time horizon, maintaining their level of response.

At the end of the titration period, nonresponding patients discontinued all drug treatments and were assumed to stay in the nonresponse health state for the remainder of the model time horizon. Patients who discontinued because of lack of response had immediate loss of treatment effect and were assigned the associated costs and utilities throughout the model’s time horizon.

The analysis compares LDX and atomoxetine administered as directed in the head-to-head study [15]. We assumed that patients who responded and tolerated treatment were adherent and persistent with treatment over the time horizon of the model, as was generally observed in the head-to-head study. This assumption is consistent with that made in the HTA model presented by King et al. [22].

Costs and benefits were not discounted, given the time horizon of 1 year. The uncertainty in the ICER estimate was explored by one-way and probabilistic sensitivity analyses (PSAs).

Quality control of model programming and verification of all input data with original sources was performed according to a prespecified test plan by health economists who were not involved in the model development.

Model Parameter Inputs

Efficacy and Safety

The base-case analysis used data generated from a head-to-head clinical study that compared LDX versus atomoxetine, the most commonly used second-line treatment in the UK in patients with ADHD who were inadequate responders to previous methylphenidate therapy [15]. Head-to-head randomized controlled trials are considered by NICE to provide the most valid evidence of relative efficacy; hence, this study was used in the economic analysis. That study was a 9-week, head-to-head, randomized, double-blind, active-controlled study (SPD489-317; ClinicalTrials.gov NCT01106430), with patients randomized 1:1 to an optimized daily dose of LDX (30, 50, or 70 mg) or atomoxetine (patients <70 kg, 0.5–1.2 mg/kg with total daily dose not exceeding 1.4 mg/kg; patients ≥70 kg, 40, 80, or 100 mg). Response to treatment, assumed in the model to be measured at the end of the titration period, was defined as a score of 1 (very much improved) or 2 (much improved), based on the last observation carried forward (LOCF) CGI-I score at week 9, which was the definition of response used in the primary outcome. This definition was also used in the trial to categorize patients into responders and nonresponders, and this outcome was selected for use in the economic analysis owing to its dichotomous nature. Response rates applied in the base-case analysis are presented in Table 1.

Table 1.

Summary of model input parameters

Description	Analysisa	Value	Range	Distribution	Source
Treatment-specific response rates
Response defined as the proportion of patients with a CGI-I value of 1 (very much improved) or 2 (much improved) out of all patients includedb
LDX	Base	81.7 %	75.0–88.5 %	Beta	[15]
ATX	Base	63.6 %	55.4–71.8 %	Beta	[15]
LDX	SA	70.3 % RR = 3.218	2.683–3.860	Log-normalc	MTC [23]
ATX	SA	45.4 % RR = 2.077	1.782–2.419	Log-normalc	MTC [23]
Response defined as the proportion of patients with a percentage reduction from baseline in ADHD-RS-IV total score of ≥25 %d
LDX	SA	72.4 %	64.7–80.2 %	Beta	Head-to-head trial data [18]
ATX	SA	63.7 %	55.6–71.8 %	Beta	Head-to-head trial data [18]
Treatment-specific withdrawal owing to AE rates
LDX	Base	6.25 %	NR	Beta	[15]
ATX	Base	7.5 %	NR	Beta	[15]
LDX	SA	3 % RR = 2.871	0.942–8.755	Log-normalc	MTC [23]
ATX	SA	1.7 % RR = 1.669	0.836–3.331	Log-normalc	MTC [23]
Health-state utilities
Responder	Base	0.837	NR	Beta	EQ-5D [24]
Nonresponder	Base	0.773	NR	Beta	EQ-5D [24]
Responder	SA	0.820	SE = 0.19	Beta	HUI2 [25]
Nonresponder	SA	0.700	SE = 0.20	Beta	HUI2 [25]
Responder	SA	0.926	0.915–0.938	Beta	Head-to-head trial data analysis [26]
Nonresponder	SA	0.905	0.886–0.924	Beta	Head-to-head trial data analysis [26]
Health-state costs (each 28 days)
Responder	Base	£99.78	£78.82–119.74	Uniform (±20 %)	Resource use estimates [27] Unit costs [28]
Nonresponder	Base	£190.25	NA	Uniform (±20 %)	Resource use estimates [27] Unit costs [28]
Responder	SA	£109.41	NA	Uniform (±20 %)	Estimates [22] Unit costs [28]
Nonresponder	SA	£162.78	NA	Uniform (±20 %)	Estimates [22] Unit costs [28]
Responder	SA	£93.38, £80.57, £67.76	Not included	Not included	−10 %, −30 %, −50 % specialist visit vs. junior doctor assumptione
Nonresponder	SA	£177.59, £152.26, £126.94	Not included	Not included	−10 %, −30 %, −50 % specialist visit vs. junior doctor assumptione
Drug costs (per 28 days)
LDX	Base	£83.02 (titration) £72.28 (post titration)f	Not included	Not included	Usage [18] Unit costs [29]
ATX	Base	£82.43 (titration) £63.03 (post titration)f	Not included	Not included	Usage [18] Unit costs [29]
LDX	SA	£83.02 (titration) £66.56 (post titration)g	Not included	Not included	Usage [30] Unit costs [29]
ATX	SA	£82.43 (titration) £107.77 (post titration)g	Not included	Not included	Usage [30] Unit costs [29]

ADHD-RS-IV Attention-Deficit/Hyperactivity Disorder Rating Scale-IV, AE adverse event, ATX atomoxetine, CGI-I Clinical Global Impression–Improvement subscale, EQ-5D EuroQol 5-Dimensions instrument, HUI2 Health Utilities Index Mark 2, LDX lisdexamfetamine dimesylate, MTC mixed-treatment comparison, NA not applicable, NR not reported, PSA probabilistic sensitivity analysis, RR relative risk, SA sensitivity analysis, SE standard error

^aBase-case analysis or sensitivity analysis

^bAssessed as the last observation carried forward at week 9

^cThe MTC outputs for response and discontinuation because of AEs were provided as RRs versus placebo. These RRs were converted in the economic model to rates using the MTC pooled placebo rates (0.218 for response and 0.010 for withdrawals). To generate PSA values, sampling was performed on RRs using log-normal distributions

^dAssessed using the result at week 9 or a non-response for those not assessed at week 9 (a non-response imputation approach to dealing with missing data)

^eThis proportion of visits to a specialist (psychiatrist or pediatrician) was costed using the unit cost for a visit to a junior doctor (foundation house officer 1 at £43 per h) rather than as a visit to a consultant

^fThis method of drug costing uses the mean doses from the head-to-head trial. In calculating the daily drug costs applied in the model, the mean daily doses for titration and post-titration periods were multiplied by the per-milligram costs. Each per-milligram cost was based on the cost of a package with a tablet size closest to the given mean daily dose. Per-cycle cost was based on a daily cost multiplied by 28 days

^gThis method of drug costing was derived from the average daily number of tablets consumed, as reported in the IMS database [30]. To calculate daily drug costs, the daily number of tablets consumed, split by tablet strength, was multiplied by the corresponding tablets’ unit costs and then weighted by the corresponding prescription volumes. The estimates of daily consumption and the prescription shares for LDX’s different tablet strengths were based on the IMS data collected in Brazil and Canada (where LDX has been used in clinical practice)

Similar proportions of patients in the LDX and atomoxetine groups experienced treatment-emergent adverse events: 92/128 (72 %) and 95/134 (71 %), respectively [15]. Therefore, short-term drug-related adverse events were not incorporated in the model. Patients’ drug tolerability in the model was based on the rates of withdrawal because of adverse events reported in the head-to-head trial of LDX versus atomoxetine (6.3 and 7.5 %, respectively) [15].

Health-State Utilities

A systematic review of the economic literature in ADHD was conducted to identify utility values for inclusion in the model (methods of this review are reported elsewhere [31]). Utility estimates associated with response and nonresponse from the study by Coghill et al. [24] were selected as relevant for the economic analysis (Table 1). These values were estimated using the EuroQol-5 Dimensions instrument (EQ-5D), which is NICE’s preferred method for obtaining utility values [21].

Resource Use and Costs

Healthcare resource utilization estimates associated with response and nonresponse were obtained from a survey of clinicians currently treating patients with ADHD in the UK [27] (Table 2). The sample consisted of 21 specialists (18 from England, two from Scotland, and one from Wales); 13 of the specialists were psychiatrists, the remaining eight were pediatricians. Unit costs from 2011–2012 UK national sources were applied to the resource utilization estimates to calculate the costs associated with nondrug healthcare resources used by responders and nonresponders. In the survey, items of healthcare resource were based on those reported by King et al. [22].

Table 2.

Resource use and costs applied in the base-case analysis

Resource item	Unit cost	Units per year	Average cost per year
Responders
Psychiatrista	£261.87	2.48	£649.44
Pediatricianb	£167.41	2.33	£390.07
GPc	£43.00	2.62	£112.66
Nursed	£49.00	2.71	£132.79
Blood teste	£3.09	0.42	£1.30
ECGf	£60.73	0.18	£10.93
Total	–	–	£1297
Nonresponders
Psychiatrista	£261.87	5.19	£1359.11
Pediatricianb	£167.41	4.1	£686.38
GPc	£43.00	4.24	£182.32
Nursed	£49.00	4.48	£219.52
Blood teste	£3.09	0.72	£2.22
ECGf	£60.73	0.39	£23.68
Total	–	–	£2473

ECG electrocardiogram, GP general practitioner, NHS National Health Service

^aSource: NHS Trusts and NHS Foundation Trusts: Mental Health—Outpatient Attendances. MHOP05—Children and Adolescent Other Services [28]

^bSource: NHS Trusts and NHS Foundation Trusts: Consultant Led—Follow up Attendance Non-Admitted Face to Face. 420—Paediatrics [28]

^cSource: 10.8b General practitioner—unit costs. Per surgery consultation lasting 11.7 min [32]

^dSource: 10.4 Nurse specialist [community]—unit costs. Per h [32]

^eSource: NHS Trusts and NHS Foundation Trusts: Direct Access—Pathology Services. DAP823—Haematology [Excluding Anti-Coagulant Services] [28]

^fSource: NHS Trusts and NHS Foundation Trusts: Direct Access—Diagnostic Services. EA47Z—Electrocardiogram Monitoring and Stress Testing [28]

Drug unit costs were obtained from the British National Formulary 2012 [29]. Drug doses used were the mean doses for the titration and maintenance periods as reported in the head-to-head trial. Drug costs were calculated using the head-to-head trial mean doses and per-milligram drug costs. Each per-milligram cost was based on the cost of a pack with the tablet size closest to the given mean dose.

Sensitivity Analyses

One-Way Sensitivity Analysis

The following summarizes the variables considered in the one-way sensitivity analysis (Table 1).

Response rates The base-case analysis used a definition of treatment response based on the LOCF CGI-I measure at week 9. A sensitivity analysis applied response rates based on the ADHD Rating Scale-IV measure, using a reduction of 25 % or greater in ADHD Rating Scale-IV score (the most commonly used threshold in ADHD trials [23]), assessed using the result at week 9 or a non-response for those not assessed at week 9 (non-responder imputation [NRI] approach). The NRI-based value for ADHD-RS score rather than the LOCF-based value was chosen to explore how the cost-effectiveness results would change when the LDX response rate decreased while the atomoxetine rate remained roughly the same. A further sensitivity analysis used response rates from a mixed-treatment comparison (MTC) analysis conducted using ADHD clinical trials in a broad ADHD population (rather than in patients with inadequate response to methylphenidate who represented the model target population) (Table 1). Despite this difference in the populations, the MTC results were used in the sensitivity analysis to explore the impact of utilizing all published clinical evidence in the model. Systematic literature review and MTC methods used are presented in the Electronic Supplementary Material (ESM) Resource 1 and 2, with further details reported elsewhere [23]; the search strategy is presented in ESM Resource 3.

Utility values In the base-case analysis, the model applied health-state utility estimates reported by Coghill et al. [24], who used the EQ-5D instrument to obtain utility values. The sensitivity analysis applied alternative utility values reported by Lloyd et al. [25], who used statistical mapping to derive utilities for responder and nonresponder health states defined using the CGI-I measure. A further sensitivity analysis applied utility data from the LDX versus atomoxetine head-to-head trial in patients who had an inadequate response to methylphenidate (Table 1) [26]. These utility values were considered particularly valuable as they were derived from the population studied in the head-to-head trial. Patients in that study were evaluated using the Health Utilities Index Mark 2 (HUI2) [33]. The self-administered, proxy-assessed version of the HUI2 consists of 15 questions used to classify a patient’s health status. In the trial, the proxy was the patient’s parent or legally authorized representative.

Resource use estimates The base-case analysis used the healthcare resource use estimates obtained from a survey of UK specialists. In the sensitivity analysis, these resource use estimates were replaced by the values reported in the HTA model [22]. To calculate the costs, the 2011–2012 UK resource unit costs were applied to these alternative values. In additional sensitivity analyses, a percentage of the visits to specialists were assumed to be consultations with junior doctors and were costed accordingly. Three analyses were performed by replacing 10, 30, and 50 % of specialist visits to pediatricians or psychiatrists with visits to junior doctors.

Drug-costing method The base-case analysis used a method of drug costing whereby the mean daily doses from the trial were used to calculate the daily drug costs. The sensitivity analysis explored the effect of applying the drug costs calculated from real-world drug utilization, rather than from drug usage reported in the trial. The real-world usage data were obtained from Canada and Brazil, where LDX has been used in clinical practice. These data were reported as the daily average consumption, presented by the numbers of tablets [30]. To calculate the corresponding costs, the tablet numbers were multiplied by tablet unit costs.

Probabilistic Sensitivity Analysis

Uncertainty in model input parameters was examined in PSAs, wherein all input parameters, apart from drug costs, which were known with certainty, were simultaneously varied using prespecified distributions reflecting the uncertainty about their true values. The prespecified distributions for each parameter included in the PSA are presented in Table 1; 1000 repeated model simulations were performed. The PSA was performed using the base-case input parameter values and using two alternative scenarios: one using efficacy distributions estimated from the MTC, and one using utility weight distributions calculated from the head-to-head trial data. PSA results for the base-case analysis were presented graphically in the form of a cost-effectiveness acceptability curve.

Results

Base-Case Analysis

The base-case analysis results are presented in Table 3. Over a time horizon of 1 year, a patient receiving LDX benefitted from 0.011 additional QALYs compared with a patient receiving atomoxetine. The estimated mean per-patient drug cost was £745 in the LDX arm and £525 in the atomoxetine arm; a difference of £220 between arms. The per-patient nondrug cost was £1607 and £1807 for patients receiving LDX and atomoxetine, respectively; thus, total costs were £2352 for LDX and £2332 for atomoxetine. The ICER of using LDX versus atomoxetine was estimated as (£2352–2332)/0.011 = £1802 per QALY (note: calculations used unrounded values).

Table 3.

Base-case analysis results (per patient)

Strategies	Total costs (£)	Total QALYs	Incremental costs (£)	Incremental QALYs	ICER (£/QALY)
ATX	2332	0.8092	–	–	–
LDX	2352	0.8202	19.68	0.011	1802

ATX atomoxetine, ICER incremental cost-effectiveness ratio, LDX lisdexamfetamine dimesylate, QALY quality-adjusted life-year

One-Way Sensitivity Analysis

The results of the one-way sensitivity analyses are summarized in Fig. 2 and Table 4. The results of the model were found to be robust to changes in the majority of the model input parameter values. The model was most sensitive to changes in assumptions about drug costs and to the use of MTC-generated response rates, with the direction of results changing from LDX being cost effective in the base case to LDX being dominant—that is, LDX was more effective and less costly.

Fig. 2.

Summary of sensitivity analysis results. ADHD-RS-IV Attention-Deficit/Hyperactivity Disorder Rating Scale-IV, CGI-I Clinical Global Impression–Improvement subscale, MTC mixed-treatment comparison, QALY quality-adjusted life-year

Table 4.

One-way sensitivity analysis results (per patient)

Input parameter	Incremental costs (£)	Incremental QALYs	ICER (£/QALY)
Base case	19.68	0.011	1802
Treatment efficacy (using ADHD-RS-IV definition from head-to-head trial) [18]	42.89	0.006	7776
Treatment efficacy (using MTC-generated CGI-I-based response rates) [23]	−38.79	0.015	Dominant: −2668
Health-state utility (using alternative estimates from published literature) [25]	19.68	0.021	961
Health-state utility (using utilities from head-to-head trial) [26]	19.68	0.004	5490
Resource use (using estimates reported in King et al. [22])	102.00	0.011	9338
10 % of specialist visits with a junior doctor	33.56	0.011	3072
30 % of specialist visits with a junior doctor	61.32	0.011	5614
50 % of specialist visits with a junior doctor	89.08	0.011	8156
Drug-costing method [30]	−349.08	0.011	Dominant: −31,959

ADHD-RS-IV Attention-Deficit/Hyperactivity Disorder Rating Scale-IV, CGI-I Clinical Global Impression–Improvement subscale, ICER incremental cost-effectiveness ratio, MTC mixed-treatment comparison, QALY quality-adjusted life-year

Probabilistic Sensitivity Analysis

The mean probabilistic ICER for the base-case analysis was estimated to be £1586 per QALY. When assuming an acceptable willingness to pay of £20,000 per QALY [21], LDX had an 86 % probability of being cost effective when compared with atomoxetine (Fig. 3). The PSA was also performed for the additional two scenario analyses. For the analysis using alternative efficacy estimates from the MTC, the mean probabilistic ICER showed that LDX was a dominant strategy compared with atomoxetine. For the analysis using utility weight distributions from the head-to-head trial, the mean probabilistic ICER was estimated at £4968 per QALY, with a 62 % probability that the ICER fell below a threshold value of £20,000 per QALY.

Fig. 3.

Cost-effectiveness acceptability curve. LDX lisdexamfetamine dimesylate, QALY quality-adjusted life-year

Discussion

ADHD in children and adolescents can be successfully treated pharmacologically, and stimulants are the first-line treatment option. However, about one-third of patients have an inadequate response to initial treatment with methylphenidate, and atomoxetine is typically used in this patient population. In a head-to-head, randomized controlled trial, LDX was shown to provide more rapid and superior symptom control than atomoxetine in children and adolescents with an inadequate response to methylphenidate. Our economic analysis used the results of the head-to-head trial to assess the cost effectiveness of LDX when compared with atomoxetine. The base-case results showed that LDX was a cost-effective option when compared with atomoxetine, with an ICER of £1802 per QALY gained. Moreover, when we used the results of the MTC as clinical inputs, therefore accounting for all available published evidence in this ADHD population, the model results showed that LDX was a dominant strategy. Sensitivity analyses confirmed the robustness of the results, showing a high likelihood of LDX being cost effective relative to atomoxetine when applying probabilistic methods.

Our model has underlying assumptions similar to those of other models used to assess the cost effectiveness of drug therapies for ADHD. The cost effectiveness of atomoxetine in stimulant-exposed UK populations was previously assessed from the NHS perspective by Cottrell et al. [11]. That study showed that inclusion of atomoxetine in the treatment algorithm was cost effective under the established threshold of £20,000 per QALY in stimulant-failed or stimulant-contraindicated populations. NICE’s current clinical recommendations for the management of ADHD in children and adolescents are based on a cost-effectiveness analysis assessing methylphenidate, atomoxetine, and dexamphetamine [22]. The optimal treatment strategy identified by that analysis suggested that methylphenidate should be used in first line, dexamphetamine in second line, with atomoxetine in third line. It also concluded that, for patients contraindicated to stimulants, atomoxetine is preferred to no treatment.

Our model found that LDX is highly cost effective relative to atomoxetine, providing better efficacy at a small increased cost. Thus, LDX would provide a good additional second-line stimulant option. The option of using LDX may be particularly valuable for patients for whom atomoxetine is contraindicated or for those patients who prefer a stimulant with an adverse-event profile that is similar to that of other established stimulants. Thus, the inclusion of a new cost-effective option in the armamentarium of ADHD treatments could allow for patients’ individual needs and preferences to be taken into consideration. Having multiple stimulant and nonstimulant treatment options available is likely to contribute to a reduction in the overall burden of ADHD.

The previous HTA economic evaluation [22] acknowledged the lack of clinical evidence to fully assess differences between various ADHD treatments. In contrast, our economic analysis used evidence generated by a randomized, head-to-head controlled trial that is considered to be at the top of the hierarchy of evidence [21, 34], although we acknowledge that certain elements of the study design (the 9-week duration and once-daily dosing regimen) may not have elicited the maximum potential treatment benefit of atomoxetine [15]. To account for this, we performed a sensitivity analysis using the results of an MTC where all clinical trials of atomoxetine were included, including those with different durations and dosing patterns. The results using the outputs of the MTC were more favorable for LDX than those using the results of the clinical trial. Another strength of our analysis is that our model used a model structure and timeframe of 1 year. This timeframe is consistent with that used in other UK-based models [11, 22, 35] and requires minimal extrapolation of the short-term data from the head-to-head trial, thus recognizing the lack of the long-term data that would be necessary to adequately inform a longer-term model.

Our study has a number of limitations that need to be considered, particularly when assessing its generalizability. However, to avoid speculation, the effects of these limitations on the model outcomes are not fully explored, given that relevant data are not available to enable these alternative analyses. First, the study was conducted from the UK NHS perspective and did not include the broader societal perspective, which is an important cost driver in the overall cost burden of ADHD. Taking into account costs associated with the societal perspective would likely result in a lower ICER for LDX. Second, the clinical data used in the analysis were derived from a single clinical trial set mainly outside of the UK. However, the European Medicines Agency considered these clinical data to be applicable to all European Union countries. Third, although this trial’s strength was in its head-to-head randomized, double-blind, parallel-group, dose-optimized design, the 9-week duration might not have elicited the maximum potential treatment benefit of atomoxetine as it has been suggested that 12 weeks is needed for atomoxetine to reach maximum response [20]. Fourth, despite evidence to suggest that LDX provides better adherence and persistence than atomoxetine [36, 37], the model did not consider real-life medication adherence because of the lack of data on the relationship between adherence to therapy and symptom reduction. Fifth, because of a lack of data, the study did not consider any treatment for nonresponders and assumed these patients discontinued drug therapy. Sixth, the utility data for intolerable side effects were not based on disutility data of individual side effects leading to discontinuation, but estimated in the model as a 50/50 % mix of the responder and nonresponder utility values. In real-world clinical practice, such patients may receive off-label medications (such as bupropion, clonidine, modafinil, and imipramine) or combination treatments [8]. Seventh, cost effectiveness of any treatment can change over time as clinical practice and medication pricing evolves. Finally, the comparisons that could be performed in this economic analysis were restricted to atomoxetine only because of a lack of data on other possible comparators, such as dexamphetamine.

Conclusions

The findings from this study support the use of LDX in the UK as a more cost-effective treatment option than atomoxetine in the treatment of children and adolescents who have experienced unsatisfactory improvements on methylphenidate.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Compliance with Ethical Standards

Ethical standards

This was a non-interventional cost-utility analysis; therefore, institutional review board approval and informed consent were deemed unnecessary. This article does not contain any studies with human participants/animals performed by any of the authors.

Funding

This study was funded by Shire Development LLC. Funding was provided to RTI Health Solutions to develop the model. Open access was funded by Shire International GmbH.

Conflict of interest

EAZ and JAM are employees of RTI Health Solutions. MB is an employee of Shire. PH and JS were employees of Shire when this work was conducted. SMB was an employee of RTI when this work was conducted and is now employed by BresMed Health Solutions, Sheffield, UK.