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. 2016 Jun 29;6(3):31. doi: 10.3390/biom6030031

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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In vitro stimulation of T cells from normal post-menopausal HLA-A*0201⁺ women with anchor-optimized or glycosylated MUC1 peptides elicited strong CTL activity. PBLs underwent two rounds of stimulation and sorted CD8⁺ T cells were subjected to a ⁵¹Cr-release assay. Data represent killing activity of various MUC1-specific CTLs generated against MCF-7 (MUC1⁺, HLA-A2⁺) cells used as targets. Effector:target ratio was 100:1 and spontaneous release was less than 15% of complete lysis. * p = 0.008 compared to the negative peptide.