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. 2016 Sep 9;6(12):2052–2067. doi: 10.7150/thno.16180

Figure 5.

Figure 5

Pulmonary fibrosis caused by crystalline silica attenuated by administrating NQDI 1. A Masson trichrome staining of collagen in lung sections of treated C57 mice at 56 days. Representative images are shown (n=5). a1-a2, saline group; b1-b2, saline+ NQDI 1 group; c1-c2, crystalline silica group; d1-d2, crystalline silica+ NQDI 1 group. a1-d1 are images of the peribronchial areas and a2-d2 are images of the alveolar areas. Scale bar, 100 μm. Magnification at 200×. B Hydroxyproline content in lung tissues from treated mice at 56 days were measured (n = 5). C Relative expression of Col-1A1 was assayed by real-time PCR (n=5 per group). All experiments were performed three times. # P<0.05 compared with the saline group; * P<0.05 compared with the crystalline silica group.