Table 4.

Comparison of different methods on the Q306 dataset

Method	γa	σb	P-valuec
I-Mutent3.0	0.12	2.04	3.7E-4
INPS	0.27	1.96	7.9E-4
mCSM	0.18	2.09	7.0E-2
STRUM	0.40	1.91

^aγ, PCC between predicted and experiment $\Delta \Delta G.$

^aσ, RMSE of $\Delta \Delta G$ prediction in Kcal/mol.

^aP-value, P-value in Wilcoxon test between the RMSE of STRUM and that by the control methods on the mutations.