Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1991 Feb;75(2):79–83. doi: 10.1136/bjo.75.2.79

Prognostic significance of the pattern visual evoked potential in ocular hypertension.

L C Bray 1, K W Mitchell 1, J W Howe 1
PMCID: PMC504118  PMID: 1995048

Abstract

This paper reports a prospective study on 49 ocular hypertensive patients to evaluate the prognostic significance of transient abnormalities in the pattern visual evoked potential (VEP) in the development of glaucoma. Seven of 24 patients with VEP abnormalities at diagnosis of ocular hypertension developed glaucomatous field defects in the follow-up period as compared with none of 25 patients with normal VEPs at diagnosis. We conclude that appropriately designed pattern VEP testing is a valuable complement to careful (preferably computerised, static) perimetry. In addition, our findings support the contention that, in glaucomatous disease of the optic nerve, rudimentary pattern processing mechanisms--that is 'Y'-type units of the magnocellular pathways--may be affected earlier than luminance processing mechanisms.

Full text

PDF
79

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Airaksinen P. J., Nieminen H. Retinal nerve fiber layer photography in glaucoma. Ophthalmology. 1985 Jul;92(7):877–879. doi: 10.1016/s0161-6420(85)33941-6. [DOI] [PubMed] [Google Scholar]
  2. Arden G. B., Jacobson J. J. A simple grating test for contrast sensitivity: preliminary results indicate value in screening for glaucoma. Invest Ophthalmol Vis Sci. 1978 Jan;17(1):23–32. [PubMed] [Google Scholar]
  3. CAMPBELL C. J., RITTLER M. C. The diagnostic value of flicker perimetry in chronic simple glaucoma. Trans Am Acad Ophthalmol Otolaryngol. 1959 Jan-Feb;63(1):89–98. [PubMed] [Google Scholar]
  4. Cappin J. M., Nissim S. Visual evoked responses in the assessment of field defects in glaucoma. Arch Ophthalmol. 1975 Jan;93(1):9–18. doi: 10.1001/archopht.1975.01010020013002. [DOI] [PubMed] [Google Scholar]
  5. Ederer F. Refereeing clinical research papers for statistical content. Am J Ophthalmol. 1985 Nov 15;100(5):735–737. doi: 10.1016/0002-9394(85)90633-6. [DOI] [PubMed] [Google Scholar]
  6. Fishman G. A., Krill A. E., Fishman M. Acquired color defects in patients with open-angle glaucoma and ocular hypertension. Mod Probl Ophthalmol. 1974;13(0):335–338. [PubMed] [Google Scholar]
  7. Gündüz K., Arden G. B., Perry S., Weinstein G. W., Hitchings R. A. Color vision defects in ocular hypertension and glaucoma. Quantification with a computer-driven color television system. Arch Ophthalmol. 1988 Jul;106(7):929–935. doi: 10.1001/archopht.1988.01060140075028. [DOI] [PubMed] [Google Scholar]
  8. Hitchings R. A., Spaeth G. L. The optic disc in glaucoma II: correlation of the appearance of the optic disc with the visual field. Br J Ophthalmol. 1977 Feb;61(2):107–113. doi: 10.1136/bjo.61.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Howe J. W., Mitchell K. W. Visual evoked cortical potential to paracentral retinal stimulation in chronic glaucoma, ocular hypertension, and an age-matched group of normals. Doc Ophthalmol. 1986 Jun 16;63(1):37–44. doi: 10.1007/BF00153010. [DOI] [PubMed] [Google Scholar]
  10. Johnson C. A., Keltner J. L., Krohn M. A., Portney G. L. Photogrammetry of the optic disc in glaucoma and ocular hypertension with simultaneous stereo photography. Invest Ophthalmol Vis Sci. 1979 Dec;18(12):1252–1263. [PubMed] [Google Scholar]
  11. Kahn H. A., Leibowitz H. M., Ganley J. P., Kini M. M., Colton T., Nickerson R. S., Dawber T. R. The Framingham Eye Study. I. Outline and major prevalence findings. Am J Epidemiol. 1977 Jul;106(1):17–32. doi: 10.1093/oxfordjournals.aje.a112428. [DOI] [PubMed] [Google Scholar]
  12. Lehmann D., Skrandies W. Multichannel evoked potential fields show different properties of human upper and lower hemiretina systems. Exp Brain Res. 1979 Mar 9;35(1):151–159. doi: 10.1007/BF00236791. [DOI] [PubMed] [Google Scholar]
  13. Marx M. S., Podos S. M., Bodis-Wollner I., Lee P. Y., Wang R. F., Severin C. Signs of early damage in glaucomatous monkey eyes: low spatial frequency losses in the pattern ERG and VEP. Exp Eye Res. 1988 Feb;46(2):173–184. doi: 10.1016/s0014-4835(88)80075-7. [DOI] [PubMed] [Google Scholar]
  14. Neima D., LeBlanc R., Regan D. Visual field defects in ocular hypertension and glaucoma. Arch Ophthalmol. 1984 Jul;102(7):1042–1045. doi: 10.1001/archopht.1984.01040030844029. [DOI] [PubMed] [Google Scholar]
  15. Odom J. V., Feghali J. G., Jin J. C., Weinstein G. W. Visual function deficits in glaucoma. Electroretinogram pattern and luminance nonlinearities. Arch Ophthalmol. 1990 Feb;108(2):222–227. doi: 10.1001/archopht.1990.01070040074034. [DOI] [PubMed] [Google Scholar]
  16. Perkins E. S. The Bedford glaucoma survey. I. Long-term follow-up of borderline cases. Br J Ophthalmol. 1973 Mar;57(3):179–185. doi: 10.1136/bjo.57.3.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Quigley H. A., Addicks E. M., Green W. R. Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. Arch Ophthalmol. 1982 Jan;100(1):135–146. doi: 10.1001/archopht.1982.01030030137016. [DOI] [PubMed] [Google Scholar]
  18. Quigley H. A., Dunkelberger G. R., Green W. R. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 1989 May 15;107(5):453–464. doi: 10.1016/0002-9394(89)90488-1. [DOI] [PubMed] [Google Scholar]
  19. Sommer A., Enger C., Witt K. Screening for glaucomatous visual field loss with automated threshold perimetry. Am J Ophthalmol. 1987 May 15;103(5):681–684. doi: 10.1016/s0002-9394(14)74329-6. [DOI] [PubMed] [Google Scholar]
  20. Takamoto T., Schwartz B. Photogrammetric measurement of nerve fiber layer thickness. Ophthalmology. 1989 Sep;96(9):1315–1319. doi: 10.1016/s0161-6420(89)32720-5. [DOI] [PubMed] [Google Scholar]
  21. Towle V. L., Moskowitz A., Sokol S., Schwartz B. The visual evoked potential in glaucoma and ocular hypertension: effects of check size, field size, and stimulation rate. Invest Ophthalmol Vis Sci. 1983 Feb;24(2):175–183. [PubMed] [Google Scholar]
  22. Wanger P., Persson H. E. Pattern-reversal electroretinograms from normotensive, hypertensive and glaucomatous eyes. Ophthalmologica. 1987;195(4):205–208. doi: 10.1159/000309814. [DOI] [PubMed] [Google Scholar]
  23. Wanger P., Persson H. E. Pattern-reversal electroretinograms in unilateral glaucoma. Invest Ophthalmol Vis Sci. 1983 Jun;24(6):749–753. [PubMed] [Google Scholar]
  24. Watts M. T., Good P. A., O'Neill E. C. The flash stimulated VEP in the diagnosis of glaucoma. Eye (Lond) 1989;3(Pt 6):732–737. doi: 10.1038/eye.1989.113. [DOI] [PubMed] [Google Scholar]
  25. Weinstein G. W., Arden G. B., Hitchings R. A., Ryan S., Calthorpe C. M., Odom J. V. The pattern electroretinogram (PERG) in ocular hypertension and glaucoma. Arch Ophthalmol. 1988 Jul;106(7):923–928. doi: 10.1001/archopht.1988.01060140069027. [DOI] [PubMed] [Google Scholar]
  26. van Lith G., Ringens P., de Heer L. J. Pattern electroretinogram and glaucoma. Dev Ophthalmol. 1984;9:133–139. doi: 10.1159/000409816. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES