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. 1992 Feb;76(2):120–122. doi: 10.1136/bjo.76.2.120

Premalignant melanosis of the conjunctiva and the cornea in xeroderma pigmentosum.

A D Paridaens 1, A C McCartney 1, J L Hungerford 1
PMCID: PMC504178  PMID: 1739708

Abstract

Xeroderma pigmentosum is a rare autosomal recessive dermatosis. The neoplastic changes in sunlight-exposed areas of the skin and eyes may be related to the impaired replication of ultraviolet radiation-damaged DNA. A 38-year-old Greek woman is reported with a mild form of xeroderma pigmentosum and primary acquired melanosis with atypia of her right limbal conjunctiva and cornea. The development of this precursor of conjunctival malignant melanoma in a xeroderma pigmentosum patient may support the putative role of sunlight exposure in malignant transformation of conjunctival melanocytes.

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Selected References

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