Figure 1. Role of HIF in tumorigenesis.

A. Development of 3-methylcholanthrene (MCA)-induced fibrosarcomas (n = 16 per genotype) and B. development of polyoma virus middle T oncoprotein (PyMT) breast cancer (n = 8 per genotype) in wt C57BL/6J, myeloid Hif-1α^LysM−/−, Hif-2α^LysM−/− and Hif-1α/2α^LysM−/− mice was assessed by palpation twice weekly. C. Mean tumor burden [(tumor weight/body weight)/number of mice)] in MCA-injected and D. PyMT mice was calculated at the end of the experiments. Bar graphs show mean values ± SEM. * P < 0.05 compared to wt mice.