Abstract
Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence of conjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multicentric non-pigmented variety of conjunctival malignant melanoma tends to present later than pigmented forms and may require exenteration of the orbit as a primary procedure.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albert D. M., Gonder J. R., Papale J., Craft J. L., Dohlman H. G., Reid M. C., Sunderman F. W., Jr Induction of ocular neoplasms in Fischer rats by intraocular injection of nickel subsulfide. Invest Ophthalmol Vis Sci. 1982 Jun;22(6):768–782. [PubMed] [Google Scholar]
- BENSON W. R. Intraocular tumor after ethionine and N-2-fluorenylacetamide. Arch Pathol. 1962 May;73:404–406. [PubMed] [Google Scholar]
- Bahn A. K., Rosenwaike I., Hermann N., Grover P., Stellman J., O'Leary K. Letter: Melanoma after exposure to PCB's. N Engl J Med. 1976 Aug 19;295(8):450–450. doi: 10.1056/NEJM197608192950820. [DOI] [PubMed] [Google Scholar]
- Clark W. H., Jr, Min B. H., Kligman L. H. The developmental biology of induced malignant melanoma in guinea pigs and a comparison with other neoplastic systems. Cancer Res. 1976 Nov;36(11 Pt 1):4079–4091. [PubMed] [Google Scholar]
- Folberg R., McLean I. W., Zimmerman L. E. Primary acquired melanosis of the conjunctiva. Hum Pathol. 1985 Feb;16(2):129–135. doi: 10.1016/s0046-8177(85)80061-7. [DOI] [PubMed] [Google Scholar]
- Griffith W. R., Green W. R., Weinstein G. W. Conjunctival malignant melanoma originating in acquired melanosis sine pigmento. Am J Ophthalmol. 1971 Sep;72(3):595–599. doi: 10.1016/0002-9394(71)90857-9. [DOI] [PubMed] [Google Scholar]
- Jakobiec F. A., Rini F. J., Fraunfelder F. T., Brownstein S. Cryotherapy for conjunctival primary acquired melanosis and malignant melanoma. Experience with 62 cases. Ophthalmology. 1988 Aug;95(8):1058–1070. doi: 10.1016/s0161-6420(88)33058-7. [DOI] [PubMed] [Google Scholar]
- PATZ A., WULFF L. B., ROGERS S. W. Experimental production of ocular tumors. Am J Ophthalmol. 1959 Jul;48(1 Pt 2):98–117. doi: 10.1016/0002-9394(59)90246-6. [DOI] [PubMed] [Google Scholar]
- Taylor G. N., Dougherty T. F., Mays C. W., Lloyd R. D., Atherton D. R., Jee W. S. Radium-induced eye melanomas in dogs. Radiat Res. 1972 Aug;51(2):361–373. [PubMed] [Google Scholar]