Figure 2. Inhibition of FGFR signaling by MPT0L145 in RT-112 cells.

A. RT-112 cells were treated with the indicated concentrations of MPT0L145 and BGJ-398 for 1 h and the levels of phosphorylated FGFR1, FGFR3 and FRS2 were detected via western blot. (B–D) Effects of MPT0L145 on FGFR downstream signaling. Cells were treated with the indicated concentrations of MPT0L145 or BGJ-398 for 1 h B. 4 h C. and 8 h D. Protein lysates were subjected to western blot analysis with the indicated antibodies.