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. 1992 Mar;76(3):179–180. doi: 10.1136/bjo.76.3.179

Exacerbation of akinetic seizures by atropine eye drops.

B D Wright 1
PMCID: PMC504203  PMID: 1540568

Abstract

A case is reported where atropine sulphate eye drops increased the frequency of fits in a child suffering regular akinetic seizures. This increase was marked and observed during two separate courses of eye drops. This is discussed with reference to previous reports of central nervous toxicity after the use of topical atropine sulphate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAKER J. P., FARLEY J. D. Toxic psychosis following atropine eye-drops. Br Med J. 1958 Dec 6;2(5109):1390–1392. doi: 10.1136/bmj.2.5109.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buzsáki G. Hippocampal sharp waves: their origin and significance. Brain Res. 1986 Nov 29;398(2):242–252. doi: 10.1016/0006-8993(86)91483-6. [DOI] [PubMed] [Google Scholar]
  3. Clinical Memoranda. Br Med J. 1937 Mar 27;1(3977):663–663. [PMC free article] [PubMed] [Google Scholar]
  4. Daniels J. C., Spehlmann R. The convulsant effect of topically applied atropine. Electroencephalogr Clin Neurophysiol. 1973 Jan;34(1):83–87. doi: 10.1016/0013-4694(73)90155-7. [DOI] [PubMed] [Google Scholar]
  5. Davidson S. I. Systemic effects of eye drops. Trans Ophthalmol Soc U K. 1974 Jul;94(2):487–495. [PubMed] [Google Scholar]
  6. Ehle A., Co S., Jones M. G. Clinical correlates of midline spikes. An analysis of 21 patients. Arch Neurol. 1981 Jun;38(6):355–357. doi: 10.1001/archneur.1981.00510060057008. [DOI] [PubMed] [Google Scholar]
  7. HEATH W. E. Death from atropine poisoning. Br Med J. 1950 Sep 9;2(4679):608–608. doi: 10.1136/bmj.2.4679.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOEFNAGEL D. Toxic effects of atropine and homatropine eyedrops in children. N Engl J Med. 1961 Jan 26;264:168–171. doi: 10.1056/NEJM196101262640403. [DOI] [PubMed] [Google Scholar]
  9. Harel L., Frydman M., Kauschansky A. Prolonged parasympathetic paralysis and psychosis caused by atropine eye drops. J Pediatr Ophthalmol Strabismus. 1985 Jan-Feb;22(1):38–39. doi: 10.3928/0191-3913-19850101-14. [DOI] [PubMed] [Google Scholar]
  10. Nadal J., De la Fuente V., Abadias M., Torrent J., Jané F. Toxic coma induced by anticholinergic eye drops. Br Med J (Clin Res Ed) 1987 Nov 21;295(6609):1352–1352. doi: 10.1136/bmj.295.6609.1352-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nelson K. R., Brenner R. P., de la Paz D. Midline spikes. EEG and clinical features. Arch Neurol. 1983 Aug;40(8):473–476. doi: 10.1001/archneur.1983.04210070013005. [DOI] [PubMed] [Google Scholar]
  12. O'Connor P. S., Mumma J. V. Atropine toxicity. Am J Ophthalmol. 1985 May 15;99(5):613–614. doi: 10.1016/s0002-9394(14)77985-1. [DOI] [PubMed] [Google Scholar]
  13. Pedley T. A., Tharp B. R., Herman K. Clinical and electroencephalographic characteristics of midline parasagittal foci. Ann Neurol. 1981 Feb;9(2):142–149. doi: 10.1002/ana.410090207. [DOI] [PubMed] [Google Scholar]
  14. Pourmand R. A., Markand O. N., Thomas C. Midline spike discharges: clinical and EEG correlates. Clin Electroencephalogr. 1984 Oct;15(4):232–236. doi: 10.1177/155005948401500409. [DOI] [PubMed] [Google Scholar]

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