Abstract
We present a patient with serologically confirmed Epstein-Barr virus (EBV) infection who had illusions of size, shape, and colour of objects but none of the typical symptoms and signs peculiar to infectious mononucleosis (IM) except sore throat which developed 2 weeks after the initial visual disturbances. The bizarre feelings about the images of body and objects are called the 'Alice in Wonderland syndrome' due to the similarity with Alice's dreams. The same symptomatology including visual metamorphosia is defined in patients with migraine, epilepsy, intoxication due to hallucinogenic drugs, schizophrenia, hyperpyrexia, and cerebral lesions. Alice in Wonderland syndrome has also been reported in the course of IM.
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Selected References
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- Copperman S. M. "Alice in Wonderland" syndrome as a presenting symptom of infectious mononucleosis in children: a description of three affected young people. Clin Pediatr (Phila) 1977 Feb;16(2):143–146. doi: 10.1177/000992287701600205. [DOI] [PubMed] [Google Scholar]
- Eshel G. M., Evov A., Lahat E., Brauman A. Alice in Wonderland syndrome, a manifestation of acute Epstein-Barr virus infection. Pediatr Infect Dis J. 1987 Jan;6(1):68–68. doi: 10.1097/00006454-198701000-00018. [DOI] [PubMed] [Google Scholar]
- Fisher M. D., Foley P., Lunsford T. The neurological sequelae of mononucleosis. Indiana Med. 1990 Mar;83(3):190–191. [PubMed] [Google Scholar]
- Graman P. S. Mollaret's meningitis associated with acute Epstein-Barr virus mononucleosis. Arch Neurol. 1987 Nov;44(11):1204–1205. doi: 10.1001/archneur.1987.00520230084023. [DOI] [PubMed] [Google Scholar]
- Hendler N., Leahy W. Psychiatric and neurologic sequelae of infectious mononucleosis. Am J Psychiatry. 1978 Jul;135(7):842–844. doi: 10.1176/ajp.135.7.842. [DOI] [PubMed] [Google Scholar]
- Lahat E., Eshel G., Arlazoroff A. "Alice in Wonderland" syndrome and infectious mononucleosis in children. J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1104–1104. doi: 10.1136/jnnp.53.12.1104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mohanaruban K., Fisher D. J. A combination of cranial and peripheral nerve palsies in infectious mononucleosis. Postgrad Med J. 1986 Dec;62(734):1129–1130. doi: 10.1136/pgmj.62.734.1129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mouallem M., Friedman E., Rubinstein E. Inappropriate antidiuretic hormone secretion with infectious mononucleosis. N Engl J Med. 1984 Jul 26;311(4):262–262. doi: 10.1056/nejm198407263110421. [DOI] [PubMed] [Google Scholar]
- Murdoch J. C. The myalgic encephalomyelitis syndrome. N Z Med J. 1989 Jul 26;102(872):372–373. [PubMed] [Google Scholar]
- Sanguineti G., Crovato F., De Marchi R., Desirello G. "Alice in Wonderland" syndrome in a patient with infectious mononucleosis. J Infect Dis. 1983 Apr;147(4):782–782. doi: 10.1093/infdis/147.4.782. [DOI] [PubMed] [Google Scholar]
- Shepherd C. Myalgic encephalomyelitis--is it a real disease? Practitioner. 1989 Jan;233(1461):41-2, 44, 46. [PubMed] [Google Scholar]
- Silber M. H. Acute transverse myelopathy in Epstein-Barr virus infection. Case reports. S Afr Med J. 1983 Oct 29;64(19):753–754. [PubMed] [Google Scholar]
- TODD J. The syndrome of Alice in Wonderland. Can Med Assoc J. 1955 Nov 1;73(9):701–704. [PMC free article] [PubMed] [Google Scholar]
- Wadhwa N. K., Ghose R. R. Acute cerebellar ataxia and infectious mononucleosis. Postgrad Med J. 1983 Jul;59(693):457–458. doi: 10.1136/pgmj.59.693.457. [DOI] [PMC free article] [PubMed] [Google Scholar]