Table 2. Cox regression analysis for the progression-free survival of patients with astrocytic Tumors.

Variable	Univariate Cox Model			Multivariate Cox Model
	HR	95%CI	p value	HR	95%CI	p value
COX model of Classification, IDH, ATRX and Ki-67
Age ≤ 42 vs.>42	1.366	0.944-1.976	0.098
Male vs. Female	0.924	0.635-1.346	0.682
IDH1-R132H positive vs. negative	0.432	0.288-0.648	4.97E-05	0.218	0.067-0.71	0.012
ATRX loss vs. expression	0.586	0.404-0.851	5.00E-03	0.941	0.559-1.585	0.82
Ki-67 expression low vs. high	1.787	1.231-2.596	0.002	2,738	1.139-6.581	0.024
Classification	1.672	1.316-2.126	2.63E-05	0.5	0.188-1.330	0.165
COX model of Classification and Grade
Classification	1.672	1.316-2.126	2.63E-05	1.512	1.062-2.153	0.022
WHO grade II/III vs. IV	1.449	1.187-1.770	2.70E-04	1.121	0.835-1.504	0.447