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. 1992 Sep;76(9):574–576. doi: 10.1136/bjo.76.9.574

Concurrent uveoretinitis and pineocytoma in a child suggests a causal relationship.

N Illum 1, H W Korf 1, K Julian 1, T Rasmussen 1, M Herning 1, S Krabbe 1
PMCID: PMC504354  PMID: 1420067

Abstract

Uveoretinitis was observed in a 9-year-old girl 6 months prior to the clinical appearance of a pineal tumour. Surgical removal was not successful but biopsy revealed a parenchymal neoplasm with differentiated pinealocytes and absent mitotic activity. Some of the tumour cells contained S-antigen, rhodopsin, and serotonin. Systemic glucocorticoid therapy followed by radiation therapy caused considerable reduction in size of the tumour and a complete normalisation of all eye symptoms. This report demonstrates for the first time that a pineocytoma can occur together with uveoretinitis in humans. The latter resembles the experimentally induced autoimmune uveoretinitis described in animals. It is speculated that the retinitis might reflect an autoimmune response to S-antigen present in some tumour cells of the pineocytoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bienfang D. C., Kelly L. D., Nicholson D. H., Nussenblatt R. B. Ophthalmology. N Engl J Med. 1990 Oct 4;323(14):956–967. doi: 10.1056/NEJM199010043231405. [DOI] [PubMed] [Google Scholar]
  2. Cohen I. R., Young D. B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today. 1991 Apr;12(4):105–110. doi: 10.1016/0167-5699(91)90093-9. [DOI] [PubMed] [Google Scholar]
  3. Disclafani A., Hudgins R. J., Edwards M. S., Wara W., Wilson C. B., Levin V. A. Pineocytomas. Cancer. 1989 Jan 15;63(2):302–304. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  4. Korf H. W., Bruce J. A., Vistica B., Rollag M., Stein B. M., Klein D. C. Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors? J Neurosurg. 1989 May;70(5):682–687. doi: 10.3171/jns.1989.70.5.0682. [DOI] [PubMed] [Google Scholar]
  5. Korf H. W., Czerwionka M., Reiner J., Schachenmayr W., Schalken J. J., de Grip W., Gery I. Immunocytochemical evidence of molecular photoreceptor markers in cerebellar medulloblastomas. Cancer. 1987 Oct 15;60(8):1763–1766. doi: 10.1002/1097-0142(19871015)60:8<1763::aid-cncr2820600815>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  6. Korf H. W., Foster R. G., Ekström P., Schalken J. J. Opsin-like immunoreaction in the retinae and pineal organs of four mammalian species. Cell Tissue Res. 1985;242(3):645–648. doi: 10.1007/BF00225432. [DOI] [PubMed] [Google Scholar]
  7. Korf H. W., Klein D. C., Zigler J. S., Gery I., Schachenmayr W. S-antigen-like immunoreactivity in a human pineocytoma. Acta Neuropathol. 1986;69(1-2):165–167. doi: 10.1007/BF00687054. [DOI] [PubMed] [Google Scholar]
  8. Korf H. W., Møller M., Gery I., Zigler J. S., Klein D. C. Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species. Cell Tissue Res. 1985;239(1):81–85. doi: 10.1007/BF00214906. [DOI] [PubMed] [Google Scholar]
  9. Merryman C. F., Donoso L. A., Zhang X. M., Heber-Katz E., Gregerson D. S. Characterization of a new, potent, immunopathogenic epitope in S-antigen that elicits T cells expressing V beta 8 and V alpha 2-like genes. J Immunol. 1991 Jan 1;146(1):75–80. [PubMed] [Google Scholar]
  10. Nussenblatt R. B., Mittal K. K., Ryan S., Green W. R., Maumenee A. E. Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol. 1982 Aug;94(2):147–158. doi: 10.1016/0002-9394(82)90069-1. [DOI] [PubMed] [Google Scholar]
  11. Perentes E., Rubinstein L. J., Herman M. M., Donoso L. A. S-antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study. Acta Neuropathol. 1986;71(3-4):224–227. doi: 10.1007/BF00688043. [DOI] [PubMed] [Google Scholar]
  12. Sternberger L. A., Hardy P. H., Jr, Cuculis J. J., Meyer H. G. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970 May;18(5):315–333. doi: 10.1177/18.5.315. [DOI] [PubMed] [Google Scholar]

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