Abstract
The velocity of blood flow in the ophthalmic artery was measured with a transcranial Doppler ultrasound (2 MHz). Sixty patients with chronic open angle glaucoma (COAG), 42 patients with normal tension glaucoma (NTG), and 35 normals were studied. Peak flow velocity (peak), mean-enveloped velocity (mean) and diastolic velocity were compared in the three groups. The COAG patients and the NTG patients showed a significant reduction of all three Doppler flow velocities compared with the normals (COAG vs normal, p = 0.013, 0.019, and 0.009; NTG vs normal, p = < 0.001, < 0.001, and < 0.001 for peak, mean and diastolic flow velocity respectively). The NTG patients also had a significant slower mean flow velocity than the COAG patients (p = 0.016), but not for peak and diastolic flow velocities (p = 0.060 and 0.052 respectively). Based on ophthalmic flow velocity values, many NTG patients and a few COAG patients had slower flow velocities than the normals. The significance of these haemodynamic differences is not yet known.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aaslid R., Markwalder T. M., Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982 Dec;57(6):769–774. doi: 10.3171/jns.1982.57.6.0769. [DOI] [PubMed] [Google Scholar]
- Becker B. Diabetes mellitus and primary open-angle glaucoma. The XXVII Edward Jackson Memorial Lecture. Am J Ophthalmol. 1971 Jan;71(1 Pt 1):1–16. doi: 10.1016/0002-9394(71)91088-9. [DOI] [PubMed] [Google Scholar]
- Carter C. J., Brooks D. E., Doyle D. L., Drance S. M. Investigations into a vascular etiology for low-tension glaucoma. Ophthalmology. 1990 Jan;97(1):49–55. doi: 10.1016/s0161-6420(90)32627-1. [DOI] [PubMed] [Google Scholar]
- Drance S. M., Douglas G. R., Wijsman K., Schulzer M., Britton R. J. Response of blood flow to warm and cold in normal and low-tension glaucoma patients. Am J Ophthalmol. 1988 Jan 15;105(1):35–39. doi: 10.1016/0002-9394(88)90118-3. [DOI] [PubMed] [Google Scholar]
- Drance S. M., Sweeney V. P., Morgan R. W., Feldman F. Studies of factors involved in the production of low tension glaucoma. Arch Ophthalmol. 1973 Jun;89(6):457–465. doi: 10.1001/archopht.1973.01000040459003. [DOI] [PubMed] [Google Scholar]
- Gasser P., Flammer J. Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma. Am J Ophthalmol. 1991 May 15;111(5):585–588. doi: 10.1016/s0002-9394(14)73703-1. [DOI] [PubMed] [Google Scholar]
- Gasser P. Ocular vasospasm: a risk factor in the pathogenesis of low-tension glaucoma. Int Ophthalmol. 1989 Jul;13(4):281–290. doi: 10.1007/BF02280088. [DOI] [PubMed] [Google Scholar]
- Guthoff R. F., Berger R. W., Winkler P., Helmke K., Chumbley L. C. Doppler ultrasonography of the ophthalmic and central retinal vessels. Arch Ophthalmol. 1991 Apr;109(4):532–536. doi: 10.1001/archopht.1991.01080040100037. [DOI] [PubMed] [Google Scholar]
- Hayreh S. S. Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. Br J Ophthalmol. 1969 Nov;53(11):721–748. doi: 10.1136/bjo.53.11.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayreh S. S. Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Doc Ophthalmol. 1985 Apr 30;59(3):217–246. doi: 10.1007/BF00159262. [DOI] [PubMed] [Google Scholar]
- Lieb W. E., Cohen S. M., Merton D. A., Shields J. A., Mitchell D. G., Goldberg B. B. Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol. 1991 Apr;109(4):527–531. doi: 10.1001/archopht.1991.01080040095036. [DOI] [PubMed] [Google Scholar]
- Martorina M., Camerlingo M. A Doppler-sonographic study in glaucoma. Ophthalmologica. 1987;194(2-3):82–85. doi: 10.1159/000309740. [DOI] [PubMed] [Google Scholar]
- McLeod S. D., West S. K., Quigley H. A., Fozard J. L. A longitudinal study of the relationship between intraocular and blood pressures. Invest Ophthalmol Vis Sci. 1990 Nov;31(11):2361–2366. [PubMed] [Google Scholar]
- Michelson G., Gierth K., Priem R., Laumer R. Blutflussgeschwindigkeit in der A. ophthalmica durch transbulbäre Dopplersonographie. Fortschr Ophthalmol. 1989;86(4):331–333. [PubMed] [Google Scholar]
- Phelps C. D., Corbett J. J. Migraine and low-tension glaucoma. A case-control study. Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1105–1108. [PubMed] [Google Scholar]
- Quigley H. A., Addicks E. M., Green W. R., Maumenee A. E. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981 Apr;99(4):635–649. doi: 10.1001/archopht.1981.03930010635009. [DOI] [PubMed] [Google Scholar]
- Rojanapongpun P., Morrison B., Drance S. M. Reproducibility of transcranial Doppler ultrasound examinations of the ophthalmic artery flow velocity. Br J Ophthalmol. 1993 Jan;77(1):22–24. doi: 10.1136/bjo.77.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]