Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1993 Jan;77(1):46–48. doi: 10.1136/bjo.77.1.46

Pinealitis accompanying equine recurrent uveitis.

C M Kalsow 1, A E Dwyer 1, A W Smith 1, T P Nifong 1
PMCID: PMC504423  PMID: 8435400

Abstract

There is no direct verification of pineal gland involvement in human uveitis. Specimens of pineal tissue are not available during active uveitis in human patients. Naturally occurring uveitis in horses gives us an opportunity to examine tissues during active ocular inflammation. We examined the pineal gland of a horse that was killed because it had become blind during an episode of uveitis. The clinical history and histopathology of the eyes were consistent with post-leptospiral equine recurrent uveitis. The pineal gland of this horse had significant inflammatory infiltration consisting mainly of lymphocytes with some eosinophils. This observation of pinealitis accompanying equine uveitis supports the animal models of experimental autoimmune uveoretinitis with associated pinealitis and suggests that the pineal gland may be involved in some human uveitides.

Full text

PDF
46

Images in this article

47Image
on p.47
47Image
on p.47
47Image
on p.47
48Image
on p.48

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe K., Matsushima S., Kachi T., Ito T. Lymphoid tissue in the pineal region of the mouse: a histological and histometrical study. Arch Histol Jpn. 1971 Oct;33(4):263–271. doi: 10.1679/aohc1950.33.263. [DOI] [PubMed] [Google Scholar]
  2. Cozzi B., Ferrandi B. The pineal gland of the horse. Morphological and histochemical results. (With notes on the donkey and mule pineal). Basic Appl Histochem. 1984;28(1):81–90. [PubMed] [Google Scholar]
  3. Cravioto H., Dart D. The ultrastructure of "pinealoma". (Seminoma-like tumor of the pineal region). J Neuropathol Exp Neurol. 1973 Oct;32(4):552–565. doi: 10.1097/00005072-197310000-00006. [DOI] [PubMed] [Google Scholar]
  4. Gery I., Wiggert B., Redmond T. M., Kuwabara T., Crawford M. A., Vistica B. P., Chader G. J. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest Ophthalmol Vis Sci. 1986 Aug;27(8):1296–1300. [PubMed] [Google Scholar]
  5. Hines M. T. Immunologically mediated ocular disease in the horse. Vet Clin North Am Large Anim Pract. 1984 Nov;6(3):501–512. doi: 10.1016/s0196-9846(17)30006-x. [DOI] [PubMed] [Google Scholar]
  6. Kalsow C. M., Dwyer A. E., Smith A. W., Nifong T. P. Pinealitis coincident with recurrent uveitis: immunohistochemical studies. Curr Eye Res. 1992;11 (Suppl):147–151. doi: 10.3109/02713689208999525. [DOI] [PubMed] [Google Scholar]
  7. Kalsow C. M., Wacker W. B. Pineal gland involvement in retina-induced experimental allergic uveitis. Invest Ophthalmol Vis Sci. 1978 Aug;17(8):774–783. [PubMed] [Google Scholar]
  8. Kalsow C. M., Wacker W. B. Pineal reactivity of anti-retina sera. Invest Ophthalmol Vis Sci. 1977 Feb;16(2):181–184. [PubMed] [Google Scholar]
  9. Kalsow C. M., Wacker W. B. Rabbit ocular and pineal autoimmune response to retina antigens. Curr Eye Res. 1986 Aug;5(8):579–586. doi: 10.3109/02713688609015122. [DOI] [PubMed] [Google Scholar]
  10. Mochizuki M., Charley J., Kuwabara T., Nussenblatt R. B., Gery I. Involvement of the pineal gland in rats with experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1333–1338. [PubMed] [Google Scholar]
  11. Neuwelt E. A., Smith R. G. Presence of lymphocyte membrane surface markers on "small cells" in a pineal germinoma. Ann Neurol. 1979 Aug;6(2):133–136. doi: 10.1002/ana.410060211. [DOI] [PubMed] [Google Scholar]
  12. Palczewski K., Carruth M. E., Adamus G., McDowell J. H., Hargrave P. A. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990;30(8):1129–1137. doi: 10.1016/0042-6989(90)90170-p. [DOI] [PubMed] [Google Scholar]
  13. ROBERTS S. J. Sequelae of leptospirosis in horses on a small farm. J Am Vet Med Assoc. 1958 Aug 15;133(4):189–194. [PubMed] [Google Scholar]
  14. ROBERTS S. R. Fundus lesions in equine periodic ophthalmia. J Am Vet Med Assoc. 1962 Jul 15;141:229–239. [PubMed] [Google Scholar]
  15. Rodrigues M. M., Hackett J., Gaskins R., Wiggert B., Lee L., Redmond M., Chader G. J. Interphotoreceptor retinoid-binding protein in retinal rod cells and pineal gland. Invest Ophthalmol Vis Sci. 1986 May;27(5):844–850. [PubMed] [Google Scholar]
  16. Sawamura Y., Hamou M. F., Kuppner M. C., de Tribolet N. Immunohistochemical and in vitro functional analysis of pineal-germinoma infiltrating lymphocytes: report of a case. Neurosurgery. 1989 Sep;25(3):454–458. doi: 10.1097/00006123-198909000-00023. [DOI] [PubMed] [Google Scholar]
  17. Tapp E., Huxley M. The histological appearance of the human pineal gland from puberty to old age. J Pathol. 1972 Oct;108(2):137–144. doi: 10.1002/path.1711080207. [DOI] [PubMed] [Google Scholar]
  18. Touitou Y., Le Hoang P., Claustrat B., Attye T., Auzeby A., Brun J., Bogdan A., Touitou C. Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. Neurosci Lett. 1986 Sep 25;70(1):170–174. doi: 10.1016/0304-3940(86)90458-1. [DOI] [PubMed] [Google Scholar]
  19. Uede T., Ishii Y., Matsuura A., Shimogawara I., Kikuchi K. Immunohistochemical study of lymphocytes in rat pineal gland: selective accumulation of T lymphocytes. Anat Rec. 1981 Feb;199(2):239–247. doi: 10.1002/ar.1091990208. [DOI] [PubMed] [Google Scholar]
  20. Vigh B., Vigh-Teichmann I. The pinealocyte forming receptor and effector endings: immunoelectron microscopy and calcium histochemistry. Arch Histol Cytol. 1989;52 (Suppl):433–440. doi: 10.1679/aohc.52.suppl_433. [DOI] [PubMed] [Google Scholar]
  21. Williams R. D., Morter R. L., Freeman M. J., Lavignette A. M. Experimental chronic uveitis. Ophthalmic signs following equine leptospirosis. Invest Ophthalmol. 1971 Dec;10(12):948–954. [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES