Abstract
Homozygous alpha+ thalassaemia (alpha-/alpha-) ameliorates some of the clinical manifestations of homozygous sickle cell (SS) disease but its effect on retinal complications remains unknown. This has been assessed by visual examination and fluorescein angiography in 39 subjects with SS disease and homozygous alpha+ thalassaemia and in 39 age/sex matched controls with SS disease but with a normal alpha globin genotype (alpha alpha/alpha alpha). The results indicate that homozygous alpha+ thalassaemia reduces the extent of peripheral retinal vessel closure but has no apparent effect on the frequency of proliferative sickle retinopathy.
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Selected References
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- Condon P. I., Hayes R. J., Serjeant G. R. Retinal and choroidal neovascularization in sickle cell disease. Trans Ophthalmol Soc U K. 1980 Sep;100(3):434–439. [PubMed] [Google Scholar]
- Hayes R. J., Condon P. I., Serjeant G. R. Haematological factors associated with proliferative retinopathy in homozygous sickle cell disease. Br J Ophthalmol. 1981 Jan;65(1):29–35. doi: 10.1136/bjo.65.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Higgs D. R., Aldridge B. E., Lamb J., Clegg J. B., Weatherall D. J., Hayes R. J., Grandison Y., Lowrie Y., Mason K. P., Serjeant B. E. The interaction of alpha-thalassemia and homozygous sickle-cell disease. N Engl J Med. 1982 Jun 17;306(24):1441–1446. doi: 10.1056/NEJM198206173062402. [DOI] [PubMed] [Google Scholar]
- Higgs D. R., Pressley L., Serjeant G. R., Clegg J. B., Weatherall D. J. The genetics and molecular basis of alpha thalassaemia in association with Hb S in Jamaican Negroes. Br J Haematol. 1981 Jan;47(1):43–56. doi: 10.1111/j.1365-2141.1981.tb02760.x. [DOI] [PubMed] [Google Scholar]
- Talbot J. F., Bird A. C., Maude G. H., Acheson R. W., Moriarty B. J., Serjeant G. R. Sickle cell retinopathy in Jamaican children: further observations from a cohort study. Br J Ophthalmol. 1988 Oct;72(10):727–732. doi: 10.1136/bjo.72.10.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Ceulaer K., Higgs D. R., Weatherall D. J., Hayes R. J., Serjeant B. E., Serjeant G. R. alpha-Thalassemia reduces the hemolytic rate in homozygous sickle-cell disease. N Engl J Med. 1983 Jul 21;309(3):189–190. doi: 10.1056/NEJM198307213090320. [DOI] [PubMed] [Google Scholar]