Table 1. Combination of carfilzomib with vorinostat induced G₂-M arrest.

Cell cycle	Control	CFZ	VOR	CFZ and VOR
MOLT-4
G0G1	44.9 + 3.1	22.8 + 1.7	44.8 + 2.7	35.8 + 3.1
G2-M	12.3 + 1.5	20.2 + 2.1**	6.8 + 1.7	35.3 + 3.6†
S	42.7 + 2.6	57.1 + 3.1	48.3 + 2.3	29.0 + 4.9
HuT 78
G0G1	54.3 + 2.7	44.2 + 1.7	54.0 + 2.7	41.2 + 1.6
G2-M	10.1 + 1.4	16.7 + 1.3**	6.3 + 1.2	38.0 + 2.6†
S	35.6 + 3.7	39.2 + 0.7	39.7 + 3.6	20.8 + 1.0

^**represent significant differences relative to controls (p < 0.01);

^†represent significant differences relative to CFZ (p < 0.001).

CFZ, carfilzomib; VOR, vorinostat.