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. 2016 Apr 18;7(20):29605–29619. doi: 10.18632/oncotarget.8812

Figure 5. Downregulation of AIB1 contributes to sorafenib-induced cell death through increasing the levels of intracellular ROS in HCC cells.

Figure 5

A. Downregulation of AIB1 increased sorafenib-induced ROS in HepG2 cells. B. MntBAP decreased sorafenib-induced cell death in HepG2 cells. C. Overexpression of AIB1 decreased sorafenib-induced ROS in SK-Hep1 cells. D. MnTBAP decreased sorafenib-induced cell death in SK-Hep1 cells. E. Downregulation of AIB1 decreased the mRNA levels of catalase and GCLC after sorafenib treatment. F. Overexpression of AIB1 increased the mRNA levels of catalase and GCLC after sorafenib treatment. All data are the mean + SD (n=3). *p < 0.05,**p < 0.01.