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. 2016 Apr 18;7(20):29620–29634. doi: 10.18632/oncotarget.8813

Figure 1. Increase of TREM-2 expression in the tumor-bearing host.

Figure 1

A. Leukocytes isolated from peripheral blood of 52 patients with lung cancer and 41 healthy controls were analyzed by flow cytometry. The percentage of TREM-2+monocytes and MFI of TREM-2 expression were shown. B. The percentage of TREM-2+monocytes and MFI of TREM-2 expression were shown in the blood of normal and tumor bearing- mice. C-E. Cells isolated from the lung, spleen, and blood of tumor-bearing mice and normal mice were double-stained with FITC-conjugated CD11c and PE-conjugated TREM-2 and were analyzed by flow cytometry. The percentage of TREM-2+ CD11c+ cells and MFI of TREM-2 expression of the lung, spleen and blood were shown. Results were presented as mean ± SEM. Numbers indicated are the average values of three independent experiments (n = 6/group). **p < 0.01 compared with healthy controls or normal mice; *p < 0.05 compared with normal mice.