Table 3.
qRT-PCR Outcomes and Descriptive Statistics for Genes Found to be Significantly Altered by BPA Exposure
| Gene | Comparison (n) | Relative Abundance | U | P Value |
|---|---|---|---|---|
| Hippocampus | ||||
| ERβ (Esr2) | ♂ BPA 25 000 (5) to ♂ Control (4) | 9.451 | 0 | .016 |
| ♂ EE 0.05 (5) to ♂ Control (4) | 8.209 | 0 | .016 | |
| Oxytocin (Oxt) | ♀ BPA 25 (5) to ♀ Control (5) | 3.729 | 2 | .032 |
| ♂ BPA 2500 (6) to ♂ Control (5) | 0.438 | 3 | .030 | |
| ♂ BPA 25 000 (4) to ♂ Control (5) | 0.434 | 1 | .032 | |
| Hypothalamus | ||||
| ERα (Esr1) | ♀ BPA 2.5 (6) to ♀ Control (5) | 6.055 | 0 | .004 |
| ♀ BPA 250 (5) to ♀ Control (5) | 5.254 | 1 | .016 | |
| ♀ BPA 25 000 (5) to ♀ Control (5) | 3.514 | 0 | .008 | |
| ERβ (Esr2) | ♀ BPA 2.5 (6) to ♀ Control (5) | 5.507 | 1 | .009 |
| ♀ BPA 250 (5) to ♀ Control (5) | 3.534 | 2 | .032 | |
| ♀ BPA 25 000 (5) to ♀ Control (5) | 2.810 | 2 | .032 | |
| ♀ Control (4) to ♂ Control (6) | 0.230 | 2 | .038 | |
| Oxytocin (Oxt) | ♀ BPA 2.5 (6) to ♀ Control (5) | 8.795 | 3 | .030 |
| ♀ BPA 250 (5) to ♀ Control (5) | 6.200 | 1 | .016 | |
| ♀ EE 0.05 (5) to ♀ Control (5) | 16.245 | 2 | .032 | |
| ♂ BPA 25 (5) to ♂ Control (5) | 20.757 | 2 | .032 | |
| ♂ Control (5) to ♂ EE 0.5 (5) | 11.965 | 0 | .008 | |
| Prostaglandin D2 synthase (Ptgds) | ♀ EE 0.5 (5) to ♀ Control (6) | 5.927 | 1 | .009 |
| ♂ EE 0.5 (5) to ♂ Control (6) | 7.365 | 2 | .017 | |
| GABA vesicular transporter (Slc32a1) | ♀ BPA 2.5 (6) to ♀ Control (6) | 5.247 | 0 | .004 |
| ♀ BPA 250 (5) to ♀ Control (5) | 4.398 | 0 | .008 | |
| ♀ BPA 25 000 (5) to ♀ Control (5) | 3.761 | 2 | .032 | |
| ♀ EE 0.05 (5) to ♀ Control (5) | 4.329 | 1 | .016 | |
| ♂ EE 0.5 (5) to ♂ Control (5) | 1.878 | 3 | .030 | |
| ♀ Control (4) to ♂ Control (6) | 0.210 | 0 | .010 | |
For each group, the sample size is listed in parentheses.