Figure 6. Subgraph isolated from the state transition graph (Fig. 5), highlighting tumor progression from the start state (1,0,0,0,0,0,1,0,0) leading to the deadlock state (1,0,1,1,1,1,1,0,1).

Each node in the graph represents a unique state of the system characterized by qualitative expression of genes in the following order: NF-κB, p21, FoxM1, PI3K, p53, MDM2, OGT, OGA, c-Myc. Activation of a particular gene/entity is indicated with “1”, whereas “0” indicates that the expression level of a gene is below the activation threshold. Nodes are shaded based on the level of betweenness centrality. Nodes and trajectories associated with tumor progression and recovery are denoted using red and green arrows, respectively.