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. 1994 May;78(5):401–408. doi: 10.1136/bjo.78.5.401

Corneal epithelial wound healing.

H S Dua 1, J A Gomes 1, A Singh 1
PMCID: PMC504797  PMID: 8025077

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aitken D., Friend J., Thoft R. A., Lee W. R. An ultrastructural study of rabbit ocular surface transdifferentiation. Invest Ophthalmol Vis Sci. 1988 Feb;29(2):224–231. [PubMed] [Google Scholar]
  2. Anderson R. A. Actin filaments in normal and migrating corneal epithelial cells. Invest Ophthalmol Vis Sci. 1977 Feb;16(2):161–166. [PubMed] [Google Scholar]
  3. Azar D. T., Spurr-Michaud S. J., Tisdale A. S., Gipson I. K. Altered epithelial-basement membrane interactions in diabetic corneas. Arch Ophthalmol. 1992 Apr;110(4):537–540. doi: 10.1001/archopht.1992.01080160115045. [DOI] [PubMed] [Google Scholar]
  4. Brewitt H. Sliding of epithelium in experimental corneal wounds. A scanning electron microscopic study. Acta Ophthalmol (Copenh) 1979;57(6):945–958. doi: 10.1111/j.1755-3768.1979.tb00525.x. [DOI] [PubMed] [Google Scholar]
  5. Bron A. J. Vortex patterns of the corneal epithelium. Trans Ophthalmol Soc U K. 1973;93(0):455–472. [PubMed] [Google Scholar]
  6. Buck R. C. Cell migration in repair of mouse corneal epithelium. Invest Ophthalmol Vis Sci. 1979 Aug;18(8):767–784. [PubMed] [Google Scholar]
  7. Buck R. C. Measurement of centripetal migration of normal corneal epithelial cells in the mouse. Invest Ophthalmol Vis Sci. 1985 Sep;26(9):1296–1299. [PubMed] [Google Scholar]
  8. Burstein N. L. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol. 1980 Jul-Aug;25(1):15–30. doi: 10.1016/0039-6257(80)90072-7. [DOI] [PubMed] [Google Scholar]
  9. Chen J. J., Tseng S. C. Abnormal corneal epithelial wound healing in partial-thickness removal of limbal epithelium. Invest Ophthalmol Vis Sci. 1991 Jul;32(8):2219–2233. [PubMed] [Google Scholar]
  10. Chung E. H., Bukusoglu G., Zieske J. D. Localization of corneal epithelial stem cells in the developing rat. Invest Ophthalmol Vis Sci. 1992 Jun;33(7):2199–2206. [PubMed] [Google Scholar]
  11. Cintron C., Kublin C. L., Covington H. Quantitative studies of corneal epithelial wound healing in rabbits. Curr Eye Res. 1981;1(9):507–516. doi: 10.3109/02713688109069176. [DOI] [PubMed] [Google Scholar]
  12. Cotsarelis G., Cheng S. Z., Dong G., Sun T. T., Lavker R. M. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989 Apr 21;57(2):201–209. doi: 10.1016/0092-8674(89)90958-6. [DOI] [PubMed] [Google Scholar]
  13. Crosson C. E., Klyce S. D., Beuerman R. W. Epithelial wound closure in the rabbit cornea. A biphasic process. Invest Ophthalmol Vis Sci. 1986 Apr;27(4):464–473. [PubMed] [Google Scholar]
  14. Davanger M., Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature. 1971 Feb 19;229(5286):560–561. doi: 10.1038/229560a0. [DOI] [PubMed] [Google Scholar]
  15. Dua H. S., Forrester J. V. Clinical patterns of corneal epithelial wound healing. Am J Ophthalmol. 1987 Nov 15;104(5):481–489. doi: 10.1016/s0002-9394(14)74105-4. [DOI] [PubMed] [Google Scholar]
  16. Dua H. S., Forrester J. V. The corneoscleral limbus in human corneal epithelial wound healing. Am J Ophthalmol. 1990 Dec 15;110(6):646–656. doi: 10.1016/s0002-9394(14)77062-x. [DOI] [PubMed] [Google Scholar]
  17. Dua H. S., Watson N. J., Mathur R. M., Forrester J. V. Corneal epithelial cell migration in humans: 'hurricane and blizzard keratopathy'. Eye (Lond) 1993;7(Pt 1):53–58. doi: 10.1038/eye.1993.12. [DOI] [PubMed] [Google Scholar]
  18. Ebato B., Friend J., Thoft R. A. Comparison of central and peripheral human corneal epithelium in tissue culture. Invest Ophthalmol Vis Sci. 1987 Sep;28(9):1450–1456. [PubMed] [Google Scholar]
  19. Ebato B., Friend J., Thoft R. A. Comparison of limbal and peripheral human corneal epithelium in tissue culture. Invest Ophthalmol Vis Sci. 1988 Oct;29(10):1533–1537. [PubMed] [Google Scholar]
  20. FRIEDENWALD J. S. Growth pressure and metaplasia of conjunctival and corneal epithelium. Doc Ophthalmol. 1951;5-6:184–192. doi: 10.1007/BF00143661. [DOI] [PubMed] [Google Scholar]
  21. Foster C. S., Lass J. H., Moran-Wallace K., Giovanoni R. Ocular toxicity of topical antifungal agents. Arch Ophthalmol. 1981 Jun;99(6):1081–1084. doi: 10.1001/archopht.1981.03930011081019. [DOI] [PubMed] [Google Scholar]
  22. Foster C. S., Pavan-Langston D. Corneal wound healing and antiviral medication. Arch Ophthalmol. 1977 Nov;95(11):2062–2067. doi: 10.1001/archopht.1977.04450110156022. [DOI] [PubMed] [Google Scholar]
  23. Friedenwald J. S., Buschke W. Some Factors Concerned in the Mitotic and Wound-Healing Activities of the Corneal Epithelium. Trans Am Ophthalmol Soc. 1944;42:371–383. [PMC free article] [PubMed] [Google Scholar]
  24. Fujikawa L. S., Foster C. S., Harrist T. J., Lanigan J. M., Colvin R. B. Fibronectin in healing rabbit corneal wounds. Lab Invest. 1981 Aug;45(2):120–129. [PubMed] [Google Scholar]
  25. Gipson I. K., Grill S. M., Spurr S. J., Brennan S. J. Hemidesmosome formation in vitro. J Cell Biol. 1983 Sep;97(3):849–857. doi: 10.1083/jcb.97.3.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Gipson I. K., Kiorpes T. C. Epithelial sheet movement: protein and glycoprotein synthesis. Dev Biol. 1982 Jul;92(1):259–262. doi: 10.1016/0012-1606(82)90170-1. [DOI] [PubMed] [Google Scholar]
  27. Goldberg M. F., Bron A. J. Limbal palisades of Vogt. Trans Am Ophthalmol Soc. 1982;80:155–171. [PMC free article] [PubMed] [Google Scholar]
  28. HANNA C., O'BRIEN J. E. Cell production and migration in the epithelial layer of the cornea. Arch Ophthalmol. 1960 Oct;64:536–539. doi: 10.1001/archopht.1960.01840010538009. [DOI] [PubMed] [Google Scholar]
  29. Haaskjold E., Sandvig K. U., Bjerknes R., Kravik K. The early cell kinetic response during healing of corneal epithelial wounds. Ophthalmic Surg. 1992 Oct;23(10):680–684. [PubMed] [Google Scholar]
  30. Haik B. G., Zimny M. L. Scanning electron microscopy of corneal wound healing in the rabbit. Invest Ophthalmol Vis Sci. 1977 Sep;16(9):787–796. [PubMed] [Google Scholar]
  31. Hanna C. Proliferation and migration of epithelial cells during corneal wound repair in the rabbit and the rat. Am J Ophthalmol. 1966 Jan;61(1):55–63. [PubMed] [Google Scholar]
  32. Harris T. M., Berry E. R., Pakurar A. S., Sheppard L. B. Biochemical transformation of bulbar conjunctiva into corneal epithelium: an electrophoretic analysis. Exp Eye Res. 1985 Nov;41(5):597–605. doi: 10.1016/0014-4835(85)90032-6. [DOI] [PubMed] [Google Scholar]
  33. Hirst L. W., Kenyon K. R., Fogle J. A., Hanninen L., Stark W. J. Comparative studies of corneal surface injury in the monkey and rabbit. Arch Ophthalmol. 1981 Jun;99(6):1066–1073. doi: 10.1001/archopht.1981.03930011066017. [DOI] [PubMed] [Google Scholar]
  34. Huang A. J., Tseng S. C. Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci. 1991 Jan;32(1):96–105. [PubMed] [Google Scholar]
  35. Huang A. J., Watson B. D., Hernandez E., Tseng S. C. Induction of conjunctival transdifferentiation on vascularized corneas by photothrombotic occlusion of corneal neovascularization. Ophthalmology. 1988 Feb;95(2):228–235. doi: 10.1016/s0161-6420(88)33211-2. [DOI] [PubMed] [Google Scholar]
  36. Kaye D. B. Epithelial response in penetrating keratoplasty. Am J Ophthalmol. 1980 Mar;89(3):381–387. doi: 10.1016/0002-9394(80)90008-2. [DOI] [PubMed] [Google Scholar]
  37. Kenyon K. R., Tseng S. C. Limbal autograft transplantation for ocular surface disorders. Ophthalmology. 1989 May;96(5):709–723. doi: 10.1016/s0161-6420(89)32833-8. [DOI] [PubMed] [Google Scholar]
  38. Khodadoust A. A., Silverstein A. M., Kenyon D. R., Dowling J. E. Adhesion of regenerating corneal epithelium. The role of basement membrane. Am J Ophthalmol. 1968 Mar;65(3):339–348. doi: 10.1016/0002-9394(68)93082-1. [DOI] [PubMed] [Google Scholar]
  39. Kinoshita S., Friend J., Kiorpes T. C., Thoft R. A. Keratin-like proteins in corneal and conjunctival epithelium are different. Invest Ophthalmol Vis Sci. 1983 May;24(5):577–581. [PubMed] [Google Scholar]
  40. Kinoshita S., Friend J., Thoft R. A. Sex chromatin of donor corneal epithelium in rabbits. Invest Ophthalmol Vis Sci. 1981 Sep;21(3):434–441. [PubMed] [Google Scholar]
  41. Kinoshita S., Kiorpes T. C., Friend J., Thoft R. A. Limbal epithelium in ocular surface wound healing. Invest Ophthalmol Vis Sci. 1982 Jul;23(1):73–80. [PubMed] [Google Scholar]
  42. Kitazawa T., Kinoshita S., Fujita K., Araki K., Watanabe H., Ohashi Y., Manabe R. The mechanism of accelerated corneal epithelial healing by human epidermal growth factor. Invest Ophthalmol Vis Sci. 1990 Sep;31(9):1773–1778. [PubMed] [Google Scholar]
  43. Kruse F. E., Chen J. J., Tsai R. J., Tseng S. C. Conjunctival transdifferentiation is due to the incomplete removal of limbal basal epithelium. Invest Ophthalmol Vis Sci. 1990 Sep;31(9):1903–1913. [PubMed] [Google Scholar]
  44. Kuwabara T., Perkins D. G., Cogan D. G. Sliding of the epithelium in experimental corneal wounds. Invest Ophthalmol. 1976 Jan;15(1):4–14. [PubMed] [Google Scholar]
  45. Lauweryns B., van den Oord J. J., Volpes R., Foets B., Missotten L. Distribution of very late activation integrins in the human cornea. An immunohistochemical study using monoclonal antibodies. Invest Ophthalmol Vis Sci. 1991 Jun;32(7):2079–2085. [PubMed] [Google Scholar]
  46. Lemp M. A., Mathers W. D. Corneal epithelial cell movement in humans. Eye (Lond) 1989;3(Pt 4):438–445. doi: 10.1038/eye.1989.65. [DOI] [PubMed] [Google Scholar]
  47. Lemp M. A., Roddy M. The effect of acetylcysteine (Mucomyst) on reepithelialization of the cornea. Ann Ophthalmol. 1974 Sep;6(9):893–895. [PubMed] [Google Scholar]
  48. Mann I. A STUDY OF EPITHELIAL REGENERATION IN THE LIVING EYE. Br J Ophthalmol. 1944 Jan;28(1):26–40. doi: 10.1136/bjo.28.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Matsuda M., Ubels J. L., Edelhauser H. F. A larger corneal epithelial wound closes at a faster rate. Invest Ophthalmol Vis Sci. 1985 Jun;26(6):897–900. [PubMed] [Google Scholar]
  50. Perry H. D., Hodes L. W., Seedor J. A., Donnenfeld E. D., McNamara T. F., Golub L. M. Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations. Cornea. 1993 Sep;12(5):379–382. doi: 10.1097/00003226-199309000-00002. [DOI] [PubMed] [Google Scholar]
  51. Petroutsos G., Guimaraes R., Giraud J., Pouliquen Y. Antibiotics and corneal epithelial wound healing. Arch Ophthalmol. 1983 Nov;101(11):1775–1778. doi: 10.1001/archopht.1983.01040020777023. [DOI] [PubMed] [Google Scholar]
  52. Pfister R. R. The healing of corneal epithelial abrasions in the rabbit: a scanning electron microscope study. Invest Ophthalmol. 1975 Sep;14(9):648–661. [PubMed] [Google Scholar]
  53. ROBB R. M., KUWABARA T. Corneal wound healing. I. The movement of polymorphonuclear leukocytes into corneal wounds. Arch Ophthalmol. 1962 Nov;68:636–642. doi: 10.1001/archopht.1962.00960030640012. [DOI] [PubMed] [Google Scholar]
  54. Schermer A., Galvin S., Sun T. T. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol. 1986 Jul;103(1):49–62. doi: 10.1083/jcb.103.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Shapiro M. S., Friend J., Thoft R. A. Corneal re-epithelialization from the conjunctiva. Invest Ophthalmol Vis Sci. 1981 Jul;21(1 Pt 1):135–142. [PubMed] [Google Scholar]
  56. Sheardown H., Wedge C., Chou L., Apel R., Rootman D. S., Cheng Y. L. Continuous epidermal growth factor delivery in corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 1993 Dec;34(13):3593–3600. [PubMed] [Google Scholar]
  57. Singh G., Foster C. S. Epidermal growth factor in alkali-burned corneal epithelial wound healing. Am J Ophthalmol. 1987 Jun 15;103(6):802–807. doi: 10.1016/s0002-9394(14)74397-1. [DOI] [PubMed] [Google Scholar]
  58. Soong H. K., Cintron C. Disparate effects of calmodulin inhibitors on corneal epithelial migration in rabbit and rat. Ophthalmic Res. 1985;17(1):27–33. doi: 10.1159/000265346. [DOI] [PubMed] [Google Scholar]
  59. Soong H. K. Vinculin in focal cell-to-substrate attachments of spreading corneal epithelial cells. Arch Ophthalmol. 1987 Aug;105(8):1129–1132. doi: 10.1001/archopht.1987.01060080131043. [DOI] [PubMed] [Google Scholar]
  60. Srinivasan B. D., Eakins K. E. The reepithelialization of rabbit cornea following single and multiple denudation. Exp Eye Res. 1979 Dec;29(6):595–600. doi: 10.1016/0014-4835(79)90014-9. [DOI] [PubMed] [Google Scholar]
  61. Stern G. A., Schemmer G. B., Farber R. D., Gorovoy M. S. Effect of topical antibiotic solutions on corneal epithelial wound healing. Arch Ophthalmol. 1983 Apr;101(4):644–647. doi: 10.1001/archopht.1983.01040010644025. [DOI] [PubMed] [Google Scholar]
  62. Thoft R. A., Friend J. Biochemical transformation of regenerating ocular surface epithelium. Invest Ophthalmol Vis Sci. 1977 Jan;16(1):14–20. [PubMed] [Google Scholar]
  63. Thoft R. A., Friend J., Murphy H. S. Ocular surface epithelium and corneal vascularization in rabbits. I. The role of wounding. Invest Ophthalmol Vis Sci. 1979 Jan;18(1):85–92. [PubMed] [Google Scholar]
  64. Thoft R. A., Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1442–1443. [PubMed] [Google Scholar]
  65. Townsend W. M. The limbal palisades of Vogt. Trans Am Ophthalmol Soc. 1991;89:721–756. [PMC free article] [PubMed] [Google Scholar]
  66. Tripathi B. J., Tripathi R. C. Hydrogen peroxide damage to human corneal epithelial cells in vitro. Implications for contact lens disinfection systems. Arch Ophthalmol. 1989 Oct;107(10):1516–1519. doi: 10.1001/archopht.1989.01070020590046. [DOI] [PubMed] [Google Scholar]
  67. Trope G. E., Liu G. S., Basu P. K. Toxic effects of topically administered Betagan, Betoptic, and Timoptic on regenerating corneal epithelium. J Ocul Pharmacol. 1988 Winter;4(4):359–366. doi: 10.1089/jop.1988.4.359. [DOI] [PubMed] [Google Scholar]
  68. Tseng S. C. Concept and application of limbal stem cells. Eye (Lond) 1989;3(Pt 2):141–157. doi: 10.1038/eye.1989.22. [DOI] [PubMed] [Google Scholar]
  69. Tseng S. C., Farazdaghi M., Rider A. A. Conjunctival transdifferentiation induced by systemic vitamin A deficiency in vascularized rabbit corneas. Invest Ophthalmol Vis Sci. 1987 Sep;28(9):1497–1504. [PubMed] [Google Scholar]
  70. Tseng S. C., Hirst L. W., Farazdaghi M., Green W. R. Goblet cell density and vascularization during conjunctival transdifferentiation. Invest Ophthalmol Vis Sci. 1984 Oct;25(10):1168–1176. [PubMed] [Google Scholar]
  71. Tseng S. C., Hirst L. W., Farazdaghi M., Green W. R. Inhibition of conjunctival transdifferentiation by topical retinoids. Invest Ophthalmol Vis Sci. 1987 Mar;28(3):538–542. [PubMed] [Google Scholar]
  72. Ubels J. L., Edelhauser H. F., Austin K. H. Healing of experimental corneal wounds treated with topically applied retinoids. Am J Ophthalmol. 1983 Mar;95(3):353–358. doi: 10.1016/s0002-9394(14)78305-9. [DOI] [PubMed] [Google Scholar]
  73. Zieske J. D., Bukusoglu G., Yankauckas M. A. Characterization of a potential marker of corneal epithelial stem cells. Invest Ophthalmol Vis Sci. 1992 Jan;33(1):143–152. [PubMed] [Google Scholar]

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