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. 1992 Nov 15;89(22):11064–11068. doi: 10.1073/pnas.89.22.11064

Uranium-loaded apoferritin with antibodies attached: molecular design for uranium neutron-capture therapy.

J F Hainfeld 1
PMCID: PMC50484  PMID: 1438316

Abstract

A method is described to deliver 235U to tumors; the isotope would then be fissioned by incident neutrons, producing localized lethal radiation sufficient for therapy. Apoferritin was loaded with an average of approximately 800 238U atoms per molecule. Stability of the loaded apoferritin in solution was improved, so that only 8% loss of uranium occurred after 8 days at pH 7. Fab' antibody fragments were covalently attached to the uranium-loaded apoferritin, and the immunoreactivity of the conjugate was 92% of that for antibody alone. Such bio-uranium constructions should provide significant advantages over boronated antibodies to meet the requirements for clinical neutron-capture therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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