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. 1995 Mar;79(3):202–206. doi: 10.1136/bjo.79.3.202

Smoking of beedies and cataract: cadmium and vitamin C in the lens and blood.

S Ramakrishnan 1, K N Sulochana 1, T Selvaraj 1, A Abdul Rahim 1, M Lakshmi 1, K Arunagiri 1
PMCID: PMC505063  PMID: 7703194

Abstract

Estimation of cadmium and vitamin C was performed in the blood and lens of smokers in three age groups up to a maximum age of 58, habituated to smoking a minimum of 10 beedies a day for many years, as well as those of non-smokers in the same age groups. Only nuclear cataracts with or without posterior or anterior subcapsular cataract were chosen. It was found that there was a significant accumulation of cadmium in both the blood and the lens of the smokers. Such an accumulation of cadmium might have a role in cataractogenesis in chronic smokers. In a similar experiment, with smokers and non-smokers of two age groups up to a maximum age of 40, both without cataract, increased levels of cadmium were found in the blood of smokers only, though the extent of accumulation was not as high as in chronic smokers of higher age groups. Vitamin C content of lens was on the lower side of normal in both chronic smokers of beedies in the two age groups and non-smokers with nuclear cataract with or without posterior and anterior subcapsular cataract, and there was no significant change brought about by smoking. Vitamin C levels in blood were towards the lower side of the normal in smokers and non-smokers with and without cataract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berger J., Shepard D., Morrow F., Taylor A. Relationship between dietary intake and tissue levels of reduced and total vitamin C in the nonscorbutic guinea pig. J Nutr. 1989 May;119(5):734–740. doi: 10.1093/jn/119.5.734. [DOI] [PubMed] [Google Scholar]
  2. Bhattacharyya M. H., Whelton B. D., Stern P. H., Peterson D. P. Cadmium accelerates bone loss in ovariectomized mice and fetal rat limb bones in culture. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8761–8765. doi: 10.1073/pnas.85.22.8761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clayton R. M., Cuthbert J., Seth J., Phillips C. I., Bartholomew R. S., Reid J. M. Epidemiological and other studies in the assessment of factors contributing to cataractogenesis. Ciba Found Symp. 1984;106:25–47. doi: 10.1002/9780470720875.ch3. [DOI] [PubMed] [Google Scholar]
  4. Dabeka R. W., Karpinski K. F., McKenzie A. D., Bajdik C. D. Survey of lead, cadmium and fluoride in human milk and correlation of levels with environmental and food factors. Food Chem Toxicol. 1986 Sep;24(9):913–921. doi: 10.1016/0278-6915(86)90318-2. [DOI] [PubMed] [Google Scholar]
  5. Flaye D. E., Sullivan K. N., Cullinan T. R., Silver J. H., Whitelocke R. A. Cataracts and cigarette smoking. The City Eye Study. Eye (Lond) 1989;3(Pt 4):379–384. doi: 10.1038/eye.1989.56. [DOI] [PubMed] [Google Scholar]
  6. Gairola C. G. Cadmium-enriched cigarette smoke-induced cytological and biochemical alterations in rat lungs. J Toxicol Environ Health. 1989;27(3):317–329. doi: 10.1080/15287398909531303. [DOI] [PubMed] [Google Scholar]
  7. Harding J. J., van Heyningen R. Beer, cigarettes and military work as risk factors for cataract. Dev Ophthalmol. 1989;17:13–16. doi: 10.1159/000416990. [DOI] [PubMed] [Google Scholar]
  8. Iyengar V., Woittiez J. Trace elements in human clinical specimens: evaluation of literature data to identify reference values. Clin Chem. 1988 Mar;34(3):474–481. [PubMed] [Google Scholar]
  9. Kuhnert B. R., Kuhnert P. M., Lazebnik N., Erhard P. The effect of maternal smoking on the relationship between maternal and fetal zinc status and infant birth weight. J Am Coll Nutr. 1988 Aug;7(4):309–316. doi: 10.1080/07315724.1988.10720248. [DOI] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Lauwerys R., Amery A., Bernard A., Bruaux P., Buchet J. P., Claeys F., De Plaen P., Ducoffre G., Fagard R., Lijnen P. Health effects of environmental exposure to cadmium: objectives, design and organization of the Cadmibel Study: a cross-sectional morbidity study carried out in Belgium from 1985 to 1989. Environ Health Perspect. 1990 Jul;87:283–289. doi: 10.1289/ehp.9087283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Loh H. S., Wilson C. W. Cigarette-smoking and cadmium. Lancet. 1972 Feb 26;1(7748):491–491. doi: 10.1016/s0140-6736(72)90147-x. [DOI] [PubMed] [Google Scholar]
  13. Pelletier O. Smoking and vitamin C levels in humans. Am J Clin Nutr. 1968 Nov;21(11):1259–1267. doi: 10.1093/ajcn/21.11.1259. [DOI] [PubMed] [Google Scholar]
  14. Preston A. M. Cigarette smoking-nutritional implications. Prog Food Nutr Sci. 1991;15(4):183–217. [PubMed] [Google Scholar]
  15. Rácz P., Erdöhelyi A. Cadmium, lead and copper concentrations in normal and senile cataractous human lenses. Ophthalmic Res. 1988;20(1):10–13. doi: 10.1159/000266248. [DOI] [PubMed] [Google Scholar]
  16. Taylor A. Role of nutrients in delaying cataracts. Ann N Y Acad Sci. 1992 Sep 30;669:111–124. doi: 10.1111/j.1749-6632.1992.tb17093.x. [DOI] [PubMed] [Google Scholar]
  17. West S., Munoz B., Emmett E. A., Taylor H. R. Cigarette smoking and risk of nuclear cataracts. Arch Ophthalmol. 1989 Aug;107(8):1166–1169. doi: 10.1001/archopht.1989.01070020232031. [DOI] [PubMed] [Google Scholar]

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