Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1995 Apr;79(4):313–317. doi: 10.1136/bjo.79.4.313

Cell cycle kinetics in pterygium at three latitudes.

S R Karukonda 1, H W Thompson 1, R W Beuerman 1, D S Lam 1, R Wilson 1, S J Chew 1, T L Steinemann 1
PMCID: PMC505091  PMID: 7742273

Abstract

The cell cycle kinetics of 93 specimens of pterygial tissue, as well as 19 specimens of normal conjunctiva, from patients at three sites representing three different latitudes (Singapore, 1 degree; Hong Kong, 22 degrees; and Little Rock, Arkansas, 34 degrees) were evaluated by flow cytometry. The results showed no difference in cellular proliferation patterns between pterygial and conjunctival tissue at any of the sites, suggesting that pterygium is not a disorder of excess cellular proliferation. Transmission electron microscopy showed extracellular matrix to be a prominent component of pterygium. Cellular proliferation patterns of primary and recurrent pterygium were not significantly different from each other. Factors associated with increased incidence of pterygium included male sex, outdoor occupation, and advanced age.

Full text

PDF
313

Images in this article

315Image
on p.315
316Image
on p.316

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austin P., Jakobiec F. A., Iwamoto T. Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. Ophthalmology. 1983 Jan;90(1):96–109. doi: 10.1016/s0161-6420(83)34594-2. [DOI] [PubMed] [Google Scholar]
  2. Campbell O. R., Amendola B. E., Brady L. W. Recurrent pterygia: results of postoperative treatment with Sr-90 applicators. Radiology. 1990 Feb;174(2):565–566. doi: 10.1148/radiology.174.2.2296667. [DOI] [PubMed] [Google Scholar]
  3. Chapman-Smith J. S. Pterygium treatment with triethylene thiophosphoramide. Aust N Z J Ophthalmol. 1992 May;20(2):129–131. doi: 10.1111/j.1442-9071.1992.tb00724.x. [DOI] [PubMed] [Google Scholar]
  4. Dusenbery K. E., Alul I. H., Holland E. J., Khan F. M., Levitt S. H. Beta irradiation of recurrent ptergia: results and complications. Int J Radiat Oncol Biol Phys. 1992;24(2):315–320. doi: 10.1016/0360-3016(92)90687-d. [DOI] [PubMed] [Google Scholar]
  5. Hayasaka S., Noda S., Yamamoto Y., Setogawa T. Postoperative instillation of mitomycin C in the treatment of recurrent pterygium. Ophthalmic Surg. 1989 Aug;20(8):580–583. [PubMed] [Google Scholar]
  6. Hill J. C., Maske R. Pathogenesis of pterygium. Eye (Lond) 1989;3(Pt 2):218–226. doi: 10.1038/eye.1989.31. [DOI] [PubMed] [Google Scholar]
  7. Hirst L. W., Sebban A., Chant D. Pterygium recurrence time. Ophthalmology. 1994 Apr;101(4):755–758. doi: 10.1016/s0161-6420(94)31270-x. [DOI] [PubMed] [Google Scholar]
  8. Krag S., Ehlers N. Excimer laser treatment of pterygium. Acta Ophthalmol (Copenh) 1992 Aug;70(4):530–533. doi: 10.1111/j.1755-3768.1992.tb02127.x. [DOI] [PubMed] [Google Scholar]
  9. Ling R. T. Treatment of pterygium using thermal cautery. Ophthalmic Surg. 1989 Jul;20(7):511–513. [PubMed] [Google Scholar]
  10. Mackenzie F. D., Hirst L. W., Battistutta D., Green A. Risk analysis in the development of pterygia. Ophthalmology. 1992 Jul;99(7):1056–1061. doi: 10.1016/s0161-6420(92)31850-0. [DOI] [PubMed] [Google Scholar]
  11. Schimmelpfennig B., Beuerman R. A technique for controlled sensory denervation of the rabbit cornea. Graefes Arch Clin Exp Ophthalmol. 1982;218(6):287–293. doi: 10.1007/BF02150440. [DOI] [PubMed] [Google Scholar]
  12. Sebban A., Hirst L. W. Pterygium recurrence rate at the Princess Alexandra Hospital. Aust N Z J Ophthalmol. 1991 Aug;19(3):203–206. doi: 10.1111/j.1442-9071.1991.tb00661.x. [DOI] [PubMed] [Google Scholar]
  13. Shaw E. L. A modified technique for conjunctival transplant. CLAO J. 1992 Apr;18(2):112–116. [PubMed] [Google Scholar]
  14. Singh G., Wilson M. R., Foster C. S. Long-term follow-up study of mitomycin eye drops as adjunctive treatment of pterygia and its comparison with conjunctival autograft transplantation. Cornea. 1990 Oct;9(4):331–334. [PubMed] [Google Scholar]
  15. Thompson H. W., Malter J. S., Steinemann T. L., Beuerman R. W. Flow cytometry measurements of the DNA content of corneal epithelial cells during wound healing. Invest Ophthalmol Vis Sci. 1991 Feb;32(2):433–436. [PubMed] [Google Scholar]
  16. Tseng S. C. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985 Jun;92(6):728–733. doi: 10.1016/s0161-6420(85)33967-2. [DOI] [PubMed] [Google Scholar]
  17. Zauberman H. Pterygium and its recurrence. Am J Ophthalmol. 1967 Jun;63(6):1780–1786. doi: 10.1016/0002-9394(67)93666-5. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES