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. 1995 Apr;79(4):350–353. doi: 10.1136/bjo.79.4.350

Corneal epithelial permeability during extended wear of disposable contact lenses versus daily wear of soft contact lenses.

L R Schurmans 1, E P Boets 1, J A van Best 1
PMCID: PMC505100  PMID: 7742282

Abstract

AIMS--The corneal epithelial permeability during extended wear of disposable contact lenses was compared with that during daily wear of soft contact lenses. The study was performed to verify whether the extended wear of disposable contact lenses would result in a higher permeability value than the daily wear of soft contact lenses. A higher permeability makes the cornea more vulnerable for bacterial infections and thus could explain the higher incidence of bacterial keratitis found in extended wear of disposable contact lenses in comparison with the daily wear of soft contact lenses. METHOD--The corneal epithelial permeability was determined by fluorophotometry in 33 healthy volunteers after the wear of soft, daily wear contact lenses for at least 6 months. Thereafter the determination was repeated in each volunteer after extended wear of disposable contact lenses for 1 month. The permeability in 34 healthy non-contact lens wearing volunteers was determined as a control. The permeability value was calculated from the amount of fluorescein that passed into the cornea after application by means of an eyebath. RESULTS--The mean permeability values after daily and extended wear were 0.032 nm/s and 0.031 nm/s, respectively. The values were not significantly different (Wilcoxon paired test p > 0.5). The mean permeability for the non-contact lens wearing controls was 0.042 nm/s. CONCLUSION--The results do not sustain the explanation that a difference in permeability value is the main cause of the increased incidence of keratitis during extended wear of disposable contact lenses in comparison with daily wear.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armitage B. S., Schoessler J. P. Overnight corneal swelling response in adapted and unadapted extended wear patients. Am J Optom Physiol Opt. 1988 Mar;65(3):155–161. doi: 10.1097/00006324-198803000-00003. [DOI] [PubMed] [Google Scholar]
  2. Boets E. P., van Best J. A., Boot J. P., Oosterhuis J. A. Corneal epithelial permeability and daily contact lens wear as determined by fluorophotometry. Curr Eye Res. 1988 May;7(5):511–514. doi: 10.3109/02713688809031805. [DOI] [PubMed] [Google Scholar]
  3. Buehler P. O., Schein O. D., Stamler J. F., Verdier D. D., Katz J. The increased risk of ulcerative keratitis among disposable soft contact lens users. Arch Ophthalmol. 1992 Nov;110(11):1555–1558. doi: 10.1001/archopht.1992.01080230055019. [DOI] [PubMed] [Google Scholar]
  4. Cohen E. J., Gonzalez C., Leavitt K. G., Arentsen J. J., Laibson P. R. Corneal ulcers associated with contact lenses including experience with disposable lenses. CLAO J. 1991 Jul;17(3):173–176. [PubMed] [Google Scholar]
  5. Dart J. K. Disease and risks associated with contact lenses. Br J Ophthalmol. 1993 Jan;77(1):49–53. doi: 10.1136/bjo.77.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Donshik P., Weinstock F. J., Wechsler S., Asbell P., Atwood J., Davis H., Farkas B., Farris R. L., Gruber E., Hartstein J. Disposable hydrogel contact lenses for extended wear. CLAO J. 1988 Oct-Dec;14(4):191–194. [PubMed] [Google Scholar]
  7. Donzis P. B., Mondino B. J., Weissman B. A., Bruckner D. A. Microbial contamination of contact lens care systems. Am J Ophthalmol. 1987 Oct 15;104(4):325–333. doi: 10.1016/0002-9394(87)90219-4. [DOI] [PubMed] [Google Scholar]
  8. Dunn J. P., Jr, Mondino B. J., Weissman B. A., Donzis P. B., Kikkawa D. O. Corneal ulcers associated with disposable hydrogel contact lenses. Am J Ophthalmol. 1989 Aug 15;108(2):113–117. doi: 10.1016/0002-9394(89)90002-0. [DOI] [PubMed] [Google Scholar]
  9. Elander T. R., Goldberg M. A., Salinger C. L., Tan J. R., Levy B., Abbott R. L. Microbial changes in the ocular environment with contact lens wear. CLAO J. 1992 Jan;18(1):53–55. [PubMed] [Google Scholar]
  10. Gruber E. The disposable contact lens: a new concept in extended wear. CLAO J. 1988 Oct-Dec;14(4):195–198. [PubMed] [Google Scholar]
  11. Kent H. D., Sanders R. J., Arentsen J. J., Cohen E. J., Laibson P. R. Pseudomonas corneal ulcer associated with disposable soft contact lenses. CLAO J. 1989 Oct-Dec;15(4):264–265. [PubMed] [Google Scholar]
  12. Killingsworth D. W., Stern G. A. Pseudomonas keratitis associated with the use of disposable soft contact lenses. Case report. Arch Ophthalmol. 1989 Jun;107(6):795–796. doi: 10.1001/archopht.1989.01070010817012. [DOI] [PubMed] [Google Scholar]
  13. Klotz S. A., Misra R. P., Butrus S. I. Contact lens wear enhances adherence of Pseudomonas aeruginosa and binding of lectins to the cornea. Cornea. 1990 Jul;9(3):266–270. [PubMed] [Google Scholar]
  14. Larkin D. F., Kilvington S., Easty D. L. Contamination of contact lens storage cases by Acanthamoeba and bacteria. Br J Ophthalmol. 1990 Mar;74(3):133–135. doi: 10.1136/bjo.74.3.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lemp M. A., Mathers W. D. Conrad Berens Lecture. Renewal of the corneal epithelium. CLAO J. 1991 Oct;17(4):258–266. [PubMed] [Google Scholar]
  16. Matthews T. D., Frazer D. G., Minassian D. C., Radford C. F., Dart J. K. Risks of keratitis and patterns of use with disposable contact lenses. Arch Ophthalmol. 1992 Nov;110(11):1559–1562. doi: 10.1001/archopht.1992.01080230059020. [DOI] [PubMed] [Google Scholar]
  17. Mertz P. H., Bouchard C. S., Mathers W. D., Goldman J., Shields W. J., Cavanagh H. D. Corneal infiltrates associated with disposable extended wear soft contact lenses: a report of nine cases. CLAO J. 1990 Oct-Dec;16(4):269–272. [PubMed] [Google Scholar]
  18. Schein O. D., Buehler P. O., Stamler J. F., Verdier D. D., Katz J. The impact of overnight wear on the risk of contact lens-associated ulcerative keratitis. Arch Ophthalmol. 1994 Feb;112(2):186–190. doi: 10.1001/archopht.1994.01090140062024. [DOI] [PubMed] [Google Scholar]
  19. Schein O. D., Glynn R. J., Poggio E. C., Seddon J. M., Kenyon K. R. The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. A case-control study. Microbial Keratitis Study Group. N Engl J Med. 1989 Sep 21;321(12):773–778. doi: 10.1056/NEJM198909213211201. [DOI] [PubMed] [Google Scholar]
  20. Schein O. D., Ormerod L. D., Barraquer E., Alfonso E., Egan K. M., Paton B. G., Kenyon K. R. Microbiology of contact lens-related keratitis. Cornea. 1989 Dec;8(4):281–285. [PubMed] [Google Scholar]
  21. Slusher M. M., Myrvik Q. N., Lewis J. C., Gristina A. G. Extended-wear lenses, biofilm, and bacterial adhesion. Arch Ophthalmol. 1987 Jan;105(1):110–115. doi: 10.1001/archopht.1987.01060010116042. [DOI] [PubMed] [Google Scholar]
  22. Temel A., Kazokoglu H., Taga Y., Orkan A. L. The effect of contact lens wear on tear immunoglobulins. CLAO J. 1991 Jan;17(1):69–71. [PubMed] [Google Scholar]
  23. Tse L. S., Callender M. G., Charles A. M. Antimicrobial effectiveness of some soft contact lens care systems. Am J Optom Physiol Opt. 1987 Nov;64(11):824–828. doi: 10.1097/00006324-198711000-00004. [DOI] [PubMed] [Google Scholar]
  24. Weissman B. A., Mondino B. J., Pettit T. H., Hofbauer J. D. Corneal ulcers associated with extended-wear soft contact lenses. Am J Ophthalmol. 1984 Apr;97(4):476–481. doi: 10.1016/s0002-9394(14)76131-8. [DOI] [PubMed] [Google Scholar]
  25. Wilson L. A., Sawant A. D., Simmons R. B., Ahearn D. G. Microbial contamination of contact lens storage cases and solutions. Am J Ophthalmol. 1990 Aug 15;110(2):193–198. doi: 10.1016/s0002-9394(14)76991-0. [DOI] [PubMed] [Google Scholar]
  26. de Kruijf E. J., Boot J. P., Laterveer L., van Best J. A., Ramselaar J. A., Oosterhuis J. A. A simple method for determination of corneal epithelial permeability in humans. Curr Eye Res. 1987 Nov;6(11):1327–1334. doi: 10.3109/02713688708997558. [DOI] [PubMed] [Google Scholar]
  27. van Klink F., Alizadeh H., He Y., Mellon J. A., Silvany R. E., McCulley J. P., Niederkorn J. Y. The role of contact lenses, trauma, and Langerhans cells in a Chinese hamster model of Acanthamoeba keratitis. Invest Ophthalmol Vis Sci. 1993 May;34(6):1937–1944. [PubMed] [Google Scholar]

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