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. 1995 May;79(5):494–497. doi: 10.1136/bjo.79.5.494

HLA typing in congenital toxoplasmosis.

C Meenken 1, A Rothova 1, L P de Waal 1, A R van der Horst 1, B J Mesman 1, A Kijlstra 1
PMCID: PMC505142  PMID: 7612565

Abstract

HLA-A, HLA-B, HLA-C, and HLA-D typing was performed in 47 mothers of patients suffering from ocular toxoplasmosis to investigate whether an immunogenetic predisposition exists for developing congenital toxoplasmosis in their offspring. No significant association between any HLA antigen was observed in the mothers of patients with ocular toxoplasmosis, although a total absence of the HLA-B51 antigen was found in this group. HLA-A, HLA-B, and HLA-C typing was also performed in their children (52 patients with ocular toxoplasmosis), to investigate a possible relation between the severity of ocular toxoplasmosis and an eventual immunogenetic factor. In the patients with ocular toxoplasmosis an increased frequency of the HLA-Bw62 antigen was observed in correlation with severe ocular involvement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akstein R. B., Wilson L. A., Teutsch S. M. Acquired toxoplasmosis. Ophthalmology. 1982 Dec;89(12):1299–1302. doi: 10.1016/s0161-6420(82)34629-1. [DOI] [PubMed] [Google Scholar]
  2. Bertrams J., Spitznas M., Rommelfanger M. Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy, and malignant choroidal melanoma. Invest Ophthalmol Vis Sci. 1978 Sep;17(9):918–920. [PubMed] [Google Scholar]
  3. Desmonts G., Couvreur J. Congenital toxoplasmosis. A prospective study of 378 pregnancies. N Engl J Med. 1974 May 16;290(20):1110–1116. doi: 10.1056/NEJM197405162902003. [DOI] [PubMed] [Google Scholar]
  4. Glasner P. D., Silveira C., Kruszon-Moran D., Martins M. C., Burnier Júnior M., Silveira S., Camargo M. E., Nussenblatt R. B., Kaslow R. A., Belfort Júnior R. An unusually high prevalence of ocular toxoplasmosis in southern Brazil. Am J Ophthalmol. 1992 Aug 15;114(2):136–144. doi: 10.1016/s0002-9394(14)73976-5. [DOI] [PubMed] [Google Scholar]
  5. Hohlfeld P., Daffos F., Thulliez P., Aufrant C., Couvreur J., MacAleese J., Descombey D., Forestier F. Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J Pediatr. 1989 Nov;115(5 Pt 1):765–769. doi: 10.1016/s0022-3476(89)80660-2. [DOI] [PubMed] [Google Scholar]
  6. Howard J. C. Immunology. Disease and evolution. Nature. 1991 Aug 15;352(6336):565–567. doi: 10.1038/352565a0. [DOI] [PubMed] [Google Scholar]
  7. Koppe J. G., Loewer-Sieger D. H., de Roever-Bonnet H. Results of 20-year follow-up of congenital toxoplasmosis. Lancet. 1986 Feb 1;1(8475):254–256. doi: 10.1016/s0140-6736(86)90785-3. [DOI] [PubMed] [Google Scholar]
  8. Nussenblatt R. B., Mittal K. K., Fuhrman S., Sharma S. D., Palestine A. G. Lymphocyte proliferative responses of patients with ocular toxoplasmosis to parasite and retinal antigens. Am J Ophthalmol. 1989 Jun 15;107(6):632–641. doi: 10.1016/0002-9394(89)90260-2. [DOI] [PubMed] [Google Scholar]
  9. Ohno S., O'Connor G. R., Kimura S. J. HLA antigens and toxoplasmic retinochoroiditis. Tohoku J Exp Med. 1977 Sep;123(1):91–94. doi: 10.1620/tjem.123.91. [DOI] [PubMed] [Google Scholar]
  10. Perkins E. S. Ocular toxoplasmosis. Br J Ophthalmol. 1973 Jan;57(1):1–17. doi: 10.1136/bjo.57.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rothova A. Ocular involvement in toxoplasmosis. Br J Ophthalmol. 1993 Jun;77(6):371–377. doi: 10.1136/bjo.77.6.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rothova A., van Knapen F., Baarsma G. S., Kruit P. J., Loewer-Sieger D. H., Kijlstra A. Serology in ocular toxoplasmosis. Br J Ophthalmol. 1986 Aug;70(8):615–622. doi: 10.1136/bjo.70.8.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Williams D. M., Grumet F. C., Remington J. S. Genetic control of murine resistance to Toxoplasma gondii. Infect Immun. 1978 Feb;19(2):416–420. doi: 10.1128/iai.19.2.416-420.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. van Knapen F. Toxoplasmosis, old stories and new facts. Int Ophthalmol. 1989 Dec;13(6):371–375. doi: 10.1007/BF02306483. [DOI] [PubMed] [Google Scholar]

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