Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1995 Nov;79(11):1046–1049. doi: 10.1136/bjo.79.11.1046

Role of glucose regulatory mechanisms in diabetic retinopathy.

R M Knott, J V Forrester
PMCID: PMC505326  PMID: 8534652

Full text

PDF
1046

Images in this article

1047Image
on p.1047
1047Image
on p.1047
1048Image
on p.1048
1048Image
on p.1048

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamis A. P., Shima D. T., Yeo K. T., Yeo T. K., Brown L. F., Berse B., D'Amore P. A., Folkman J. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1993 Jun 15;193(2):631–638. doi: 10.1006/bbrc.1993.1671. [DOI] [PubMed] [Google Scholar]
  2. Barnett A. H. Origin of the microangiopathic changes in diabetes. Eye (Lond) 1993;7(Pt 2):218–222. doi: 10.1038/eye.1993.52. [DOI] [PubMed] [Google Scholar]
  3. Boam D. S., Docherty K. A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer. Biochem J. 1989 Nov 15;264(1):233–239. doi: 10.1042/bj2640233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bressler J., Goldstein G. W. Effect of elevated ambient glucose upon polyphosphoinositide turnover in bovine retinal endothelial cells and rat astrocytes. Exp Eye Res. 1992 Jun;54(6):871–877. doi: 10.1016/0014-4835(92)90150-q. [DOI] [PubMed] [Google Scholar]
  5. Colville C. A., Seatter M. J., Gould G. W. Analysis of the structural requirements of sugar binding to the liver, brain and insulin-responsive glucose transporters expressed in oocytes. Biochem J. 1993 Sep 15;294(Pt 3):753–760. doi: 10.1042/bj2940753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Daneman D., Zinman B., Elliott M. E., Bilan P. J., Klip A. Insulin-stimulated glucose transport in circulating mononuclear cells from nondiabetic and IDDM subjects. Diabetes. 1992 Feb;41(2):227–234. doi: 10.2337/diab.41.2.227. [DOI] [PubMed] [Google Scholar]
  7. Devaskar S., Zahm D. S., Holtzclaw L., Chundu K., Wadzinski B. E. Developmental regulation of the distribution of rat brain insulin-insensitive (Glut 1) glucose transporter. Endocrinology. 1991 Sep;129(3):1530–1540. doi: 10.1210/endo-129-3-1530. [DOI] [PubMed] [Google Scholar]
  8. Docherty K., Clark A. R. Nutrient regulation of insulin gene expression. FASEB J. 1994 Jan;8(1):20–27. doi: 10.1096/fasebj.8.1.8299887. [DOI] [PubMed] [Google Scholar]
  9. Forrester J. V., Shafiee A., Schröder S., Knott R., McIntosh L. The role of growth factors in proliferative diabetic retinopathy. Eye (Lond) 1993;7(Pt 2):276–287. doi: 10.1038/eye.1993.61. [DOI] [PubMed] [Google Scholar]
  10. Freedman S. F., Hatchell D. L. Enhanced superoxide radical production by stimulated polymorphonuclear leukocytes in a cat model of diabetes. Exp Eye Res. 1992 Nov;55(5):767–773. doi: 10.1016/0014-4835(92)90181-q. [DOI] [PubMed] [Google Scholar]
  11. Gould G. W., Bell G. I. Facilitative glucose transporters: an expanding family. Trends Biochem Sci. 1990 Jan;15(1):18–23. doi: 10.1016/0968-0004(90)90125-u. [DOI] [PubMed] [Google Scholar]
  12. Hiraki Y., Rosen O. M., Birnbaum M. J. Growth factors rapidly induce expression of the glucose transporter gene. J Biol Chem. 1988 Sep 25;263(27):13655–13662. [PubMed] [Google Scholar]
  13. Iijima K., Yoshikawa N., Connolly D. T., Nakamura H. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor. Kidney Int. 1993 Nov;44(5):959–966. doi: 10.1038/ki.1993.337. [DOI] [PubMed] [Google Scholar]
  14. James D. E., Brown R., Navarro J., Pilch P. F. Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature. 1988 May 12;333(6169):183–185. doi: 10.1038/333183a0. [DOI] [PubMed] [Google Scholar]
  15. Kahn B. B., Flier J. S. Regulation of glucose-transporter gene expression in vitro and in vivo. Diabetes Care. 1990 Jun;13(6):548–564. doi: 10.2337/diacare.13.6.548. [DOI] [PubMed] [Google Scholar]
  16. Karnieli E., Armoni M. Regulation of glucose transporters in diabetes. Horm Res. 1990;33(2-4):99–104. doi: 10.1159/000181491. [DOI] [PubMed] [Google Scholar]
  17. King G. L., Goodman A. D., Buzney S., Moses A., Kahn C. R. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest. 1985 Mar;75(3):1028–1036. doi: 10.1172/JCI111764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Knott R. M., Robertson M., Forrester J. V. Regulation of glucose transporter (GLUT 3) and aldose reductase mRNA inbovine retinal endothelial cells and retinal pericytes in high glucose and high galactose culture. Diabetologia. 1993 Sep;36(9):808–812. doi: 10.1007/BF00400354. [DOI] [PubMed] [Google Scholar]
  19. Knott R. M., Trayhurn P., Hesketh J. E. Changes in insulin-receptor mRNA levels in skeletal muscle and brown adipose tissue of weanling rats during fasting and refeeding. Br J Nutr. 1992 Nov;68(3):583–592. doi: 10.1079/bjn19920117. [DOI] [PubMed] [Google Scholar]
  20. Kumagai A. K., Glasgow B. J., Pardridge W. M. GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci. 1994 May;35(6):2887–2894. [PubMed] [Google Scholar]
  21. Mandarino L. J., Finlayson J., Hassell J. R. High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells. Invest Ophthalmol Vis Sci. 1994 Mar;35(3):964–972. [PubMed] [Google Scholar]
  22. McAvoy J. W., Chamberlain C. G. Growth factors in the eye. Prog Growth Factor Res. 1990;2(1):29–43. doi: 10.1016/0955-2235(90)90008-8. [DOI] [PubMed] [Google Scholar]
  23. McClain D. A., Paterson A. J., Roos M. D., Wei X., Kudlow J. E. Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8150–8154. doi: 10.1073/pnas.89.17.8150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Montesano R., Orci L. Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell. 1985 Sep;42(2):469–477. doi: 10.1016/0092-8674(85)90104-7. [DOI] [PubMed] [Google Scholar]
  25. Pardridge W. M., Triguero D., Farrell C. R. Downregulation of blood-brain barrier glucose transporter in experimental diabetes. Diabetes. 1990 Sep;39(9):1040–1044. doi: 10.2337/diab.39.9.1040. [DOI] [PubMed] [Google Scholar]
  26. Pekala P., Marlow M., Heuvelman D., Connolly D. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. J Biol Chem. 1990 Oct 25;265(30):18051–18054. [PubMed] [Google Scholar]
  27. Read M. L., Clark A. R., Docherty K. The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer. Biochem J. 1993 Oct 1;295(Pt 1):233–237. doi: 10.1042/bj2950233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rollins B. J., Morrison E. D., Usher P., Flier J. S. Platelet-derived growth factor regulates glucose transporter expression. J Biol Chem. 1988 Nov 15;263(32):16523–16526. [PubMed] [Google Scholar]
  29. Schröder S., Palinski W., Schmid-Schönbein G. W. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol. 1991 Jul;139(1):81–100. [PMC free article] [PubMed] [Google Scholar]
  30. Shiba T., Inoguchi T., Sportsman J. R., Heath W. F., Bursell S., King G. L. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov;265(5 Pt 1):E783–E793. doi: 10.1152/ajpendo.1993.265.5.E783. [DOI] [PubMed] [Google Scholar]
  31. Simorre-Pinatel V., Guerrin M., Chollet P., Penary M., Clamens S., Malecaze F., Plouet J. Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway. Invest Ophthalmol Vis Sci. 1994 Aug;35(9):3393–3400. [PubMed] [Google Scholar]
  32. Sivitz W. I., DeSautel S. L., Kayano T., Bell G. I., Pessin J. E. Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin. Mol Endocrinol. 1990 Apr;4(4):583–588. doi: 10.1210/mend-4-4-583. [DOI] [PubMed] [Google Scholar]
  33. Takata K., Kasahara T., Kasahara M., Ezaki O., Hirano H. Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. Invest Ophthalmol Vis Sci. 1992 Feb;33(2):377–383. [PubMed] [Google Scholar]
  34. Waldbillig R. J., Arnold D. R., Fletcher R. T., Chader G. J. Insulin and IGF-I binding in developing chick neural retina and pigment epithelium: a characterization of binding and structural differences. Exp Eye Res. 1991 Jul;53(1):13–22. doi: 10.1016/0014-4835(91)90139-6. [DOI] [PubMed] [Google Scholar]
  35. Walker P. S., Donovan J. A., Van Ness B. G., Fellows R. E., Pessin J. E. Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells. J Biol Chem. 1988 Oct 25;263(30):15594–15601. [PubMed] [Google Scholar]
  36. Welsh M., Nielsen D. A., MacKrell A. J., Steiner D. F. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem. 1985 Nov 5;260(25):13590–13594. [PubMed] [Google Scholar]
  37. Xia P., Inoguchi T., Kern T. S., Engerman R. L., Oates P. J., King G. L. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep;43(9):1122–1129. doi: 10.2337/diab.43.9.1122. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES