Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1995 Dec;79(12):1098–1101. doi: 10.1136/bjo.79.12.1098

Long term effect of apraclonidine.

S V Araujo 1, J B Bond 1, R P Wilson 1, M R Moster 1, C M Schmidt Jr 1, G L Spaeth 1
PMCID: PMC505348  PMID: 8562543

Abstract

AIMS--To evaluate the effect of the chronic use of apraclonidine 0.5% on the intraocular pressure (IOP) of patients with glaucoma; also, to study the side effect profile of this drug when used chronically. METHODS--All patients who had uncontrolled IOP, who were either already on glaucoma medications, or who were intolerant of other glaucoma medications were enrolled. A total of 185 patients were started on apraclonidine 0.5% two to three times a day in one eye. RESULTS--Follow up extended to 35 weeks. The mean difference in IOP between treated and control eyes was 2.1 (SD 5.0) mm Hg. A similar IOP lowering effect was obtained comparing IOP difference from baseline in the treated eye only. CONCLUSION--By the end of the follow up period, 46% of patients were still on the medication. The drug was stopped in 23% of patients because of side effects and in 31% of patients because of failure to lower IOP significantly.

Full text

PDF
1098

Images in this article

1099Image
on p.1099

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrams D. A., Robin A. L., Pollack I. P., deFaller J. M., DeSantis L. The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers. Arch Ophthalmol. 1987 Sep;105(9):1205–1207. doi: 10.1001/archopht.1987.01060090063028. [DOI] [PubMed] [Google Scholar]
  2. Brown R. H., Stewart R. H., Lynch M. G., Crandall A. S., Mandell A. I., Wilensky J. T., Schwartz A. L., Gaasterland D. E., DeFaller J. M., Higginbotham E. J. ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery. Ophthalmology. 1988 Mar;95(3):378–384. doi: 10.1016/s0161-6420(88)33185-4. [DOI] [PubMed] [Google Scholar]
  3. Cullom R. D., Jr, Schwartz L. W. The effect of apraclonidine on the intraocular pressure of glaucoma patients following Nd:YAG laser posterior capsulotomy. Ophthalmic Surg. 1993 Sep;24(9):623–626. [PubMed] [Google Scholar]
  4. Flach A. J., Kramer S. G. Supersensitivity to topical epinephrine after long-term epinephrine therapy. Arch Ophthalmol. 1980 Mar;98(3):482–483. doi: 10.1001/archopht.1980.01020030478007. [DOI] [PubMed] [Google Scholar]
  5. Gharagozloo N. Z., Relf S. J., Brubaker R. F. Aqueous flow is reduced by the alpha-adrenergic agonist, apraclonidine hydrochloride (ALO 2145). Ophthalmology. 1988 Sep;95(9):1217–1220. doi: 10.1016/s0161-6420(88)33038-1. [DOI] [PubMed] [Google Scholar]
  6. Holmwood P. C., Chase R. D., Krupin T., Rosenberg L. F., Ruderman J. M., Tallman B. A., Brodstein D. E., Chopra H., Goldenfeld M. Apraclonidine and argon laser trabeculoplasty. Am J Ophthalmol. 1992 Jul 15;114(1):19–22. doi: 10.1016/s0002-9394(14)77407-0. [DOI] [PubMed] [Google Scholar]
  7. Hong C., Song K. Y., Park W. H., Sohn Y. H. Effect of apraclonidine hydrochloride on acute introacular pressure rise after argon laser iridotomy. Korean J Ophthalmol. 1991 Jun;5(1):37–41. doi: 10.3341/kjo.1991.5.1.37. [DOI] [PubMed] [Google Scholar]
  8. Hurvitz L. M., Kaufman P. L., Robin A. L., Weinreb R. N., Crawford K., Shaw B. New developments in the drug treatment of glaucoma. Drugs. 1991 Apr;41(4):514–532. doi: 10.2165/00003495-199141040-00002. [DOI] [PubMed] [Google Scholar]
  9. Innemee H. C., Hermans A. J., van Zwieten P. A. The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 Nov;212(1):19–27. doi: 10.1007/BF00413321. [DOI] [PubMed] [Google Scholar]
  10. Jampel H. D., Robin A. L., Quigley H. A., Pollack I. P. Apraclonidine. A one-week dose-response study. Arch Ophthalmol. 1988 Aug;106(8):1069–1073. doi: 10.1001/archopht.1988.01060140225029. [DOI] [PubMed] [Google Scholar]
  11. Lee D. A., Topper J. E., Brubaker R. F. Effect of clonidine on aqueous humor flow in normal human eyes. Exp Eye Res. 1984 Mar;38(3):239–246. doi: 10.1016/0014-4835(84)90162-3. [DOI] [PubMed] [Google Scholar]
  12. Nagasubramanian S., Hitchings R. A., Demailly P., Chuniaud M., Pannarale M. R., Pecori-Giraldi J., Stodtmeister R., Parsons D. G. Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. Ophthalmology. 1993 Sep;100(9):1318–1323. doi: 10.1016/s0161-6420(13)31818-1. [DOI] [PubMed] [Google Scholar]
  13. Novack G. D., Robin A. L., Derick R. J. New medical treatments for glaucoma. Int Ophthalmol Clin. 1993 Fall;33(4):183–202. doi: 10.1097/00004397-199303340-00015. [DOI] [PubMed] [Google Scholar]
  14. Pollack I. P., Brown R. H., Crandall A. S., Robin A. L., Stewart R. H., White G. L. Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical 1% apraclonidine. Arch Ophthalmol. 1988 Jun;106(6):754–757. doi: 10.1001/archopht.1988.01060130824031. [DOI] [PubMed] [Google Scholar]
  15. Robin A. L., Pollack I. P., House B., Enger C. Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty. Arch Ophthalmol. 1987 May;105(5):646–650. doi: 10.1001/archopht.1987.01060050064039. [DOI] [PubMed] [Google Scholar]
  16. Robin A. L., Pollack I. P., deFaller J. M. Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy. Arch Ophthalmol. 1987 Sep;105(9):1208–1211. doi: 10.1001/archopht.1987.01060090066029. [DOI] [PubMed] [Google Scholar]
  17. Robin A. L. Questions concerning the role of apraclonidine in the management of glaucoma. Arch Ophthalmol. 1995 Jun;113(6):712–714. doi: 10.1001/archopht.1995.01100060036026. [DOI] [PubMed] [Google Scholar]
  18. Robin A. L. Short-term effects of unilateral 1% apraclonidine therapy. Arch Ophthalmol. 1988 Jul;106(7):912–915. doi: 10.1001/archopht.1988.01060140058024. [DOI] [PubMed] [Google Scholar]
  19. Shin D. H. Bilateral effects of monocular timolol treatment. Am J Ophthalmol. 1986 Aug 15;102(2):275–276. doi: 10.1016/0002-9394(86)90159-5. [DOI] [PubMed] [Google Scholar]
  20. Silverstone D. E., Brint S. F., Olander K. W., Taylor R. B., McCarty G. R., deFaller J. M., Burk L. L. Prophylactic use of apraclonidine for intraocular pressure increase after Nd:YAG capsulotomies. Am J Ophthalmol. 1992 Apr 15;113(4):401–405. doi: 10.1016/s0002-9394(14)76162-8. [DOI] [PubMed] [Google Scholar]
  21. Wilkerson M., Lewis R. A., Shields M. B. Follicular conjunctivitis associated with apraclonidine. Am J Ophthalmol. 1991 Jan 15;111(1):105–106. doi: 10.1016/s0002-9394(14)76907-7. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES