Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Biomaterials. 2016 Sep 19;109:69–77. doi: 10.1016/j.biomaterials.2016.09.013

Figure 1.

Figure 1

Schematic of multimodal MR/Upconversion luminescent imaging of HCC tumor using transcatheter hepatic intra-arterial (IA) targeted anti-CD44-Nd-CSUCNPs. Multi-modal imaging reporters, Nd-CSUCNPs conjugated with an anti-CD44 monoclonal antibody, were delivered intra-arterially for the sensitive and rapid detection of HCC in orthotopic HCC rat models. IA delivery of multi-modality Nd-CSUCNPs conjugated with specific tumor targeting molecules facilitates rapid and selective targeting of Nd-CSUCNPs to HCC, providing strong image-contrast between the tumors and normal hepatic tissue. Next, the feasibility of multimodal diagnostic MR and intraoperative UCL image-guided surgery for HCC resection was demonstrated.