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. 1996 Dec;80(12):1046–1050. doi: 10.1136/bjo.80.12.1046

Teletherapy for subfoveal choroidal neovascularisation of age-related macular degeneration: results of follow up in a non-randomised study.

P M Hart 1, U Chakravarthy 1, G MacKenzie 1, D B Archer 1, R F Houston 1
PMCID: PMC505700  PMID: 9059267

Abstract

AIM: A preliminary report indicated stable or improved vision in 12 of 19 patients with subfoveal choroidal neovascularisation treated with 12 or 15 Gy of 6 MV photons to the affected macula after an average follow up of 18 months. Here the prolonged follow up findings in this group of treated patients is reported which was further increased to 41. METHODS: Forty one patients with subfoveal choroidal neovascularisation were treated with 10, 12, or 15 Gy of 6 MV photons to the macula of the affected eye. Thirteen eyes of 12 patients were also observed as a non-randomised comparison group. RESULTS: At 12, 18, and 24 months of follow up the mean change in visual acuity in eyes treated with radiotherapy was less than 1 Bailey-Lovie line from that measured at presentation. By contrast, the eyes in the comparison group lost 3.7 lines of acuity at 12 months which increased to 4.5 at 24 months. These differences were highly significant at each of the time points. When initial visual acuity was taken into account, treated eyes lost on average 12% of baseline acuity throughout follow up, whereas eyes belonging to the untreated group lost 50% of baseline acuity at 1 year, and 75% at 2 years. There was no significant difference in visual outcome between the three dose regimens used, which may simply be a reflection of the small sample size in each group. There was no evidence of radiation induced retinopathy or optic neuropathy in any treated patients. CONCLUSIONS: Teletherapy appeared to have a treatment effect in eyes with subfoveal choroidal neovascularisation resulting in maintained visual function without significant radiation induced morbidity.

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Selected References

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  1. Aristizabal S., Caldwell W. L., Avila J. The relationship of time-dose fractionation factors to complications in the treatment of pituitary tumors by irradiation. Int J Radiat Oncol Biol Phys. 1977 Jul-Aug;2(7-8):667–673. doi: 10.1016/0360-3016(77)90046-3. [DOI] [PubMed] [Google Scholar]
  2. Berger A. S., Kaplan H. J. Clinical experience with the surgical removal of subfoveal neovascular membranes. Short-term postoperative results. Ophthalmology. 1992 Jun;99(6):969–976. doi: 10.1016/s0161-6420(92)31869-x. [DOI] [PubMed] [Google Scholar]
  3. Bergink G. J., Deutman A. F., van den Broek J. E., van Daal W. A., van der Maazen R. M. Radiation therapy for age-related subfoveal choroidal neovascular membranes. A pilot study. Doc Ophthalmol. 1995;90(1):67–74. doi: 10.1007/BF01203296. [DOI] [PubMed] [Google Scholar]
  4. Bergink G. J., Deutman A. F., van den Broek J. F., van Daal W. A., van der Maazen R. W. Radiation therapy for subfoveal choroidal neovascular membranes in age-related macular degeneration. A pilot study. Graefes Arch Clin Exp Ophthalmol. 1994 Oct;232(10):591–598. doi: 10.1007/BF00193119. [DOI] [PubMed] [Google Scholar]
  5. Bird A. C. Recent advances in the treatment of senile disciform macular degeneration by photocoagulation. Br J Ophthalmol. 1974 Apr;58(4):367–376. doi: 10.1136/bjo.58.4.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bressler N. M., Bressler S. B., Gragoudas E. S. Clinical characteristics of choroidal neovascular membranes. Arch Ophthalmol. 1987 Feb;105(2):209–213. doi: 10.1001/archopht.1987.01060020063030. [DOI] [PubMed] [Google Scholar]
  7. Chakravarthy U., Houston R. F., Archer D. B. Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study. Br J Ophthalmol. 1993 May;77(5):265–273. doi: 10.1136/bjo.77.5.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gillies M. C., Sarks J. P., Beaumont P. E., Hunyor A. B., McKay D., Kearns M., McClusky P. J., Sarks S. H. Treatment of choroidal neovascularisation in age-related macular degeneration with interferon alfa-2a and alfa-2b. Br J Ophthalmol. 1993 Dec;77(12):759–765. doi: 10.1136/bjo.77.12.759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Harris J. R., Levene M. B. Visual complications following irradiation for pituitary adenomas and craniopharyngiomas. Radiology. 1976 Jul;120(1):167–171. doi: 10.1148/120.1.167. [DOI] [PubMed] [Google Scholar]
  10. Kirkpatrick J. N., Dick A. D., Forrester J. V. Clinical experience with interferon alfa-2a for exudative age-related macular degeneration. Br J Ophthalmol. 1993 Dec;77(12):766–770. doi: 10.1136/bjo.77.12.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Miller M. L., Goldberg S. H., Bullock J. D. Radiation retinopathy after standard radiotherapy for thyroid-related ophthalmopathy. Am J Ophthalmol. 1991 Nov 15;112(5):600–601. doi: 10.1016/s0002-9394(14)76869-2. [DOI] [PubMed] [Google Scholar]
  12. Rodger F. C. Some practical conclusions following a longitudinal study of common macular lesions. Trans Ophthalmol Soc U K. 1982 Apr;102(Pt 1):187–197. [PubMed] [Google Scholar]
  13. Thomas M. A., Grand M. G., Williams D. F., Lee C. M., Pesin S. R., Lowe M. A. Surgical management of subfoveal choroidal neovascularization. Ophthalmology. 1992 Jun;99(6):952–976. doi: 10.1016/s0161-6420(92)31888-3. [DOI] [PubMed] [Google Scholar]

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