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Reduction in non-human sequence content. The non-human sequence content, defined by alignments to DP47 and DPK9, is shown for the variable regions of (a) murine RK35 (b) RK35 1.0/1.0 and (c) RK35 1.5/1.4. Here red is the non-human sequence content and orange is the CDRH3 residues which do not align to germline.
