Figure 5. Microglia cells mediate TRAM-34-induced neuroprotection against GBM toxicity.

Hippocampal cultures, treated with empty (grey bars) or clodronate-filled liposomes (white bars) were co-cultured or not (C) with GL261 cells and treated with vehicle, TMZ, TRAM-34 or both (T+T). Results are expressed as percentage of cell survival, taking C as 100%. ***p<0.001; # p<0.05; § p<0.05; °°° p<0.001; n=3, One-Way ANOVA, Student-Newman-Keuls post-test.