Table 4. Multivariate analysis.

	Progression Free Survival			Overall Survival
	HR	95% CI	P value	HR	95% CI	P value
Age (< 60 or ≥ 60)	1.361	0.973–1.904	0.072	1.501	1.082–2.083	0.015
Operation (yes or no)	1.121	0.784–1.603	0.531	1.756	1.202–2.564	0.004
Type (diffuse or intestinal)	1.095	0.901–1.331	0.363	0.941	0.769–1.151	0.552
Number of metastasis (1 or > 1)	1.274	1.034–1.568	0.023	1.042	0.843–1.289	0.703
IGFBP1 rs4619 (AA or AG/GG)	0.575	0.385–0.858	0.007	0.707	0.484–1.031	0.072
IGF1R rs7166558 (AA/AG or GG)	0.809	0.181–3.617	0.782	1.874	0.245–14.31	0.545
IGF1R rs2229765 (AA or AG/GG)	1.004	0.241–4.183	0.996	2.563	0.347–18.93	0.356
IGF1R rs12437963 (AA or AG/GG)	1.114	0.694–1.789	0.655	1.139	0.705–1.843	0.595
IGF1R rs2872060 (GG/GT or TT)	1.379	0.849–2.240	0.195	1.708	1.024–2.850	0.040
IGF1R rs17847203 (CC or CT)	2.530	1.289–4.966	0.007	2.087	1.070–4.069	0.031