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A & B. TET1 knockdown increases promoter methylation of hMLH1 and IRX1 but not p53 in NCI-N87 cell. C. TET1 knockdown decreases 5-hmC content in hMLH1 and IRX1 promoter but not p53. D & E. TET1 over-expression decreases promoter methylation of hMLH1 and IRX1 but not p53 in SGC-7901 cell. F. TET1 over-expression increases 5-hmC content in hMLH1 and IRX1 promoter but not p53.
