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. 2016 Aug 10;41(12):2893–2902. doi: 10.1038/npp.2016.101

Table 1. Baseline Characteristicsa.

Characteristic Placebo n=144 ABT-126 25 mg n=66 ABT-126 50 mg n=151 ABT-126 75 mg n=70
Age, y, mean (SD) 42.4 (11.40) 40.7 (9.92) 40.1 (12.08) 40.8 (11.22)
         
Sex, n (%)
 Male 81 (56.3) 30 (45.5) 79 (52.3) 34 (48.6)
 Female 63 (43.8) 36 (54.5) 72 (47.7) 36 (51.4)
         
Race, n (%)
 White 101 (70.1) 42 (63.6) 103 (68.2) 50 (71.4)
 Black 40 (27.8) 22 (33.3) 45 (29.8) 17 (24.3)
 All otherb 3 (2.1) 2 (3.0) 3 (2.0) 3 (4.3)
         
Tobacco use, n (%)
 Former 34 (23.8) 14 (21.2) 38 (25.2) 21 (30.0)
 Never 109 (76.2) 52 (78.8) 113 (74.8) 49 (70.0)
 Unknown 1 (0.7) 0 0 0
         
Psychiatric history
 Years since schizophrenia diagnosis, mean (SD) 15.5 (10.57) 16.0 (9.77) 13.9 (9.92) 15.8 (9.94)
Number of prior psychiatric hospitalizations in last 2 years, n (%)
  0 106 (73.6) 43 (65.2) 112 (73.7) 50 (71.4)
  1 27 (18.8) 16 (24.2) 28 (18.4) 13 (18.6)
  2 10 (6.9) 4 (6.1) 9 (5.9) 7 (10.0)
  3 1 (0.7) 1 (1.5) 0 0
  4 0 2 (3.0) 3 (2.0) 0
Efficacy measures at baseline, mean (SD)
MCCB neurocognitive composite score
  Primary set 28.24 (12.91) 28.74 (11.98)
  Dose-ranging set 28.66 (12.34) 29.13 (12.00) 29.58 (11.71) 29.25 (11.59)
MCCB composite score
  Primary set 25.25 (13.31) 25.39 (12.31)
  Dose-ranging set 25.71 (12.52) 26.18 (12.46) 26.45 (12.07) 26.24 (11.48)
UPSA-2ER total scorec
  Primary set 65.94 (16.23) 65.08 (16.10)
  Dose-ranging set 68.58 (15.05) 68.31 (14.18) 65.40 (14.88) 67.12 (15.20)
NSA-16 total score
  Primary set 48.94 (11.34) 48.83 (11.22)
  Dose-ranging set 47.55 (11.19) 48.10 (11.42) 48.15 (9.92) 48.42 (9.21)
PANSS total score
  Primary set 66.25 (13.49) 66.95 (13.18)
  Dose-ranging set 64.37 (11.66) 66.82 (12.49) 68.34 (12.00) 66.18 (10.74)

Abbreviations: MCCB, MATRICS Consensus Cognitive Battery; NSA-16, 16-item version of the Negative Symptom Assessment scale; PANSS, Positive and Negative Symptom Scale; SD, standard deviation; UPSA-2ER, University of California San Diego Performance-based Skills Assessment-2 Extended-Range.

a

Safety dataset unless otherwise stated.

b

Includes Asian, multi-race, and Hawaiian native.

c

Excludes the medication management subscale as it is not included in the ex-US version.