Figure 2.

Active sites of A) FAAH (PDB code: 1MT5)6 and B) COX‐2 (PDB code: 3PGH)20 in complex with the substrate analogue methyl arachidonyl fluorophosphonate (MAFP) and with arachidonic acid (AA), respectively. The hydrophilic (light blue) and hydrophobic (orange) isocontour surfaces of the proteins are shown. The protein is shown as a transparent cyan tube. The ligand (yellow) and key protein residues (cyan) are shown as sticks. Adapted with permission from Ref. 14. Copyright the American Chemical Society, 2012.14