Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1992 Dec 15;89(24):11755–11758. doi: 10.1073/pnas.89.24.11755

Modulation of synaptic gain by light.

S M Wu 1, X L Yang 1
PMCID: PMC50635  PMID: 1465393

Abstract

Although synaptic transmission in the retina has been assumed to be static, it appears that the voltage gains of the synapses between photoreceptors and second-order cells can be enhanced by light. Voltage gains of the synapses between rods and bipolar (or horizontal) cells are about 10 times higher in the presence of dim background light than in darkness. This increase in synaptic gain may compensate for the loss of rod light responsiveness caused by weak background light so that the animal can maintain good rod sensitivity under moonlight or starlight, the natural lighting condition for mating and food catching.

Full text

PDF
11755

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Attwell D., Borges S., Wu S. M., Wilson M. Signal clipping by the rod output synapse. Nature. 1987 Aug 6;328(6130):522–524. doi: 10.1038/328522a0. [DOI] [PubMed] [Google Scholar]
  2. Attwell D., Mobbs P., Tessier-Lavigne M., Wilson M. Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum. J Physiol. 1987 Jun;387:125–161. doi: 10.1113/jphysiol.1987.sp016567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bader C. R., Bertrand D., Schwartz E. A. Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina. J Physiol. 1982 Oct;331:253–284. doi: 10.1113/jphysiol.1982.sp014372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Belgum J. H., Copenhagen D. R. Synaptic transfer of rod signals to horizontal and bipolar cells in the retina of the toad (Bufo marinus). J Physiol. 1988 Feb;396:225–245. doi: 10.1113/jphysiol.1988.sp016960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fain G. L. Sensitivity of toad rods: Dependence on wave-length and background illumination. J Physiol. 1976 Sep;261(1):71–101. doi: 10.1113/jphysiol.1976.sp011549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heidelberger R., Matthews G. Inhibition of calcium influx and calcium current by gamma-aminobutyric acid in single synaptic terminals. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7135–7139. doi: 10.1073/pnas.88.16.7135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Matthews H. R., Fain G. L., Murphy R. L., Lamb T. D. Light adaptation in cone photoreceptors of the salamander: a role for cytoplasmic calcium. J Physiol. 1990 Jan;420:447–469. doi: 10.1113/jphysiol.1990.sp017922. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Normann R. A., Perlman I. Signal transmission from red cones to horizontal cells in the turtle retina. J Physiol. 1979 Jan;286:509–524. doi: 10.1113/jphysiol.1979.sp012634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Torre V., Matthews H. R., Lamb T. D. Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rods. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7109–7113. doi: 10.1073/pnas.83.18.7109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wu S. M. Synaptic connections between neurons in living slices of the larval tiger salamander retina. J Neurosci Methods. 1987 Jun;20(2):139–149. doi: 10.1016/0165-0270(87)90046-x. [DOI] [PubMed] [Google Scholar]
  11. Wu S. M. Synaptic transmission from rods to horizontal cells in dark-adapted tiger salamander retina. Vision Res. 1988;28(1):1–8. [PubMed] [Google Scholar]
  12. Yang X. L., Wu S. M. Coexistence and function of glutamate receptor subtypes in the horizontal cells of the tiger salamander retina. Vis Neurosci. 1991 Oct;7(4):377–382. doi: 10.1017/s0952523800004867. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES