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. 2016 Jul 19;7(5):196–202. doi: 10.1080/21541264.2016.1210370

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© 2016 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — The ecdysteroid biosynthesis pathway and the role of Ouija board on spookier expression in the fruit fly Drosophila melanogaster. In the prothoracic gland (insect steroidogenic organ), cholesterol and other sterols are converted into ecdysteroids via several intermediate steps. The modifications on carbon residues and the responsible enzymes are indicated with red and green, respectively. In the nucleus, nvd and spok are located in the heterochromatin region. A zinc finger transcription factor named “Ouija board (Ouib)” specifically binds to the promoter region of “spookier” and induces expression of this gene. Both Ouib and Spok are essential for ecdysteroid biosynthesis during larval development.