Table 3.
Genomic Variants Associated with Hydroxyurea-Induced HbF Level
| Gene | SNPs | Chromosome: locus | References |
|---|---|---|---|
| HBB | rs7482144 | 11:5254939 | Friedrisch et al. (2008); Adekile (2011) |
| BCL11A | rs1427407 | 2:60490908 | Ware et al. (2011); Ware (2013); Friedrisch et al. (2008); Adekile (2011) |
| rs4671393 | 2:60491212 | ||
| rs7606173 | 3:60493111 | ||
| rs7557939 | 2:60494212 | ||
| rs1186868 | 2:61764103 | ||
| ARG1/2 | rs2295644 | 14:67599842 | Friedrisch et al. (2008); Adekile (2011) |
| rs17599586 | 6:131583579 | ||
| rs28384513 | 6:135055071 | ||
| HBS1L-MYB | rs9399137 | 6:135097880 | Friedrisch et al. (2008); Adekile (2011) |
| SAR1 | rs2310991 | 3:142444839 | Kumkhaek et al. (2008); Zhu et al. (2014) |
| rs4282891 | 10:70171890 | ||
| rs76901216 | 10:70170313 | ||
| SALL2 | rs61743453 | 14:21523209 | Sheehan et al. (2013) |
| FLT1 | rs2182008 | 13:28412924 | Ma et al. (2007) |
| rs8002446 | 13:28423263 | ||
| rs9319428 | 13:28399484 | ||
| rs3751395 | 13:28384818 | ||
| rs2387634 | 13:28416291 | ||
| TOX | rs826729 | 8:58826354 | Ma et al. (2007) |
| rs765587 | 8:58878344 | ||
| rs9693712 | 8:59034864 | ||
| rs172652 | 8:59045582 | ||
| rs380620 | 8:59069973 | ||
| rs2693430 | 8:58812489 | ||
| rs12155519 | 8:58936271 | ||
| ARG2 | rs10483801 | 14:67650289 | Ma et al. (2007) |
| rs10483802 | 14:67650704 | ||
| NOS1 | rs816361 | 12:117217326 | Ma et al. (2007) |
| rs7977109 | 12:117292535 | ||
| rs7309163 | 12:117291469 | ||
| NOS2A | rs1137933 | 17:27778906 | Ma et al. (2007) |
| rs944725 | 17:27782545 | ||
| MAP3K5 | rs9376230 | 6:136781227 | Ma et al. (2007) |
| rs9483947 | 6:136784262 | ||
| PDE7B | rs11154849 | 6:136032167 | Ma et al. (2007) |
| rs9376173 | 6:136038308 | ||
| rs1480642 | 6:136178390 | ||
| rs487278 | 6:136180690 | ||
| HAO2 | rs10494225 | 1:119375480 | Ma et al. (2007) |
| KLF10 | rs3191333 | 8:102649991 | Borg et al. (2012) |
SNP, single-nucleotide polymorphism.