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. 2016 Aug 15;204(2):483–497. doi: 10.1534/genetics.116.189308

Table 7 .

Power to detect pleiotropy when associated traits have β=0.25 (explain 2% trait variation; power = 90% for marginal effect)

No. associated traits (β=0.25) Trait correlation Nominal type I error rate
0.05 0.01
2 0.2 0.503 0.237
0.5 0.801 0.581
0.8 0.971 0.900
3 0.2 0.859 0.677
0.5 0.956 0.858
0.8 0.999 0.998
5 0.2 0.980 0.928
0.5 0.999 0.985
0.8 1.000 1.000

Shown is a multivariate normal distribution with equal correlation structure, for a sample size of 500 subjects and minor allele frequency of genetic variant set to 0.20.