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. 1992 Dec 15;89(24):12103–12107. doi: 10.1073/pnas.89.24.12103

Patterns of spatiotemporal organization in an "ambiquitous" enzyme model.

P Marmillot 1, J F Hervagault 1, G R Welch 1
PMCID: PMC50706  PMID: 1465446

Abstract

Many enzymes in pathways such as glycolysis associate reversibly with cellular substructures. The spatiotemporal behavior of a "limit-cycle" oscillation model is studied under the condition that the "ambiquitous" oscillophor, phosphofructokinase, is partitioned between "bulk-phase" and "bound" forms in a heterogeneous system. Computer simulation demonstrates the occurrence of sustained, wave-like spatiotemporal patterns of chemical concentration in the bulk medium. Kinetic dissimilarity among the localized populations of bound enzyme leads to a "polarity" effect in the wave phenomenon. It is suggested that a key physiological role of the limit-cycle regime is to engender a rapid, site-to-site, signal-transmission modality in large eukaryotic (e.g., mammalian) cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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