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. 1996 Mar 15;97(6):1545–1549. doi: 10.1172/JCI118577

Potentiation of the immune response in HIV-1+ individuals.

T Schmitz 1, R Underwood 1, R Khiroya 1, W W Bachovchin 1, B T Huber 1
PMCID: PMC507215  PMID: 8617888

Abstract

T cells from HIV-1+ individuals have a defect in mounting an antigen specific response. HIV-1 Tat has been implicated as the causative agent of this immunosuppression. We have previously shown that HIV-1 Tat inhibits antigen specific proliferation of normal T cells in vitro by binding to the accessory molecule CD26, a dipeptidase expressed on the surface of activated T cells. We now demonstrate that the defective in vitro recall antigen response in HIV-1 infected individuals can be restored by the addition of soluble CD26, probably by serving as a decoy receptor for HIV-1 Tat. The restored response is comparable to that of an HIV-1- individual, suggesting that early in HIV infection there is a block in the memory cell response, rather than deletion of these cells.

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Selected References

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