Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1996 Apr 1;97(7):1557–1560. doi: 10.1172/JCI118579

Transgenesis in the rat and larger mammals.

L J Mullins 1, J J Mullins 1
PMCID: PMC507217  PMID: 8601618

Full Text

The Full Text of this article is available as a PDF (91.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonifer C., Vidal M., Grosveld F., Sippel A. E. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J. 1990 Sep;9(9):2843–2848. doi: 10.1002/j.1460-2075.1990.tb07473.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carver A. S., Dalrymple M. A., Wright G., Cottom D. S., Reeves D. B., Gibson Y. H., Keenan J. L., Barrass J. D., Scott A. R., Colman A. Transgenic livestock as bioreactors: stable expression of human alpha-1-antitrypsin by a flock of sheep. Biotechnology (N Y) 1993 Nov;11(11):1263–1270. doi: 10.1038/nbt1193-1263. [DOI] [PubMed] [Google Scholar]
  3. Clark A. J., Bissinger P., Bullock D. W., Damak S., Wallace R., Whitelaw C. B., Yull F. Chromosomal position effects and the modulation of transgene expression. Reprod Fertil Dev. 1994;6(5):589–598. doi: 10.1071/rd9940589. [DOI] [PubMed] [Google Scholar]
  4. Dorling A., Lechler R. I. Prospects for xenografting. Curr Opin Immunol. 1994 Oct;6(5):765–769. doi: 10.1016/0952-7915(94)90082-5. [DOI] [PubMed] [Google Scholar]
  5. Dunn C. S., Mehtali M., Houdebine L. M., Gut J. P., Kirn A., Aubertin A. M. Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits. J Gen Virol. 1995 Jun;76(Pt 6):1327–1336. doi: 10.1099/0022-1317-76-6-1327. [DOI] [PubMed] [Google Scholar]
  6. Ebert K. M., Selgrath J. P., DiTullio P., Denman J., Smith T. E., Memon M. A., Schindler J. E., Monastersky G. M., Vitale J. A., Gordon K. Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Biotechnology (N Y) 1991 Sep;9(9):835–838. doi: 10.1038/nbt0991-835. [DOI] [PubMed] [Google Scholar]
  7. Eyestone W. H. Challenges and progress in the production of transgenic cattle. Reprod Fertil Dev. 1994;6(5):647–652. doi: 10.1071/rd9940647. [DOI] [PubMed] [Google Scholar]
  8. First N. L., Sims M. M., Park S. P., Kent-First M. J. Systems for production of calves from cultured bovine embryonic cells. Reprod Fertil Dev. 1994;6(5):553–562. doi: 10.1071/rd9940553. [DOI] [PubMed] [Google Scholar]
  9. Fodor W. L., Williams B. L., Matis L. A., Madri J. A., Rollins S. A., Knight J. W., Velander W., Squinto S. P. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11153–11157. doi: 10.1073/pnas.91.23.11153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hammer R. E., Maika S. D., Richardson J. A., Tang J. P., Taurog J. D. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell. 1990 Nov 30;63(5):1099–1112. doi: 10.1016/0092-8674(90)90512-d. [DOI] [PubMed] [Google Scholar]
  11. Iannaccone P. M., Taborn G. U., Garton R. L., Caplice M. D., Brenin D. R. Pluripotent embryonic stem cells from the rat are capable of producing chimeras. Dev Biol. 1994 May;163(1):288–292. doi: 10.1006/dbio.1994.1146. [DOI] [PubMed] [Google Scholar]
  12. Kumar S., Clarke A. R., Hooper M. L., Horne D. S., Law A. J., Leaver J., Springbett A., Stevenson E., Simons J. P. Milk composition and lactation of beta-casein-deficient mice. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6138–6142. doi: 10.1073/pnas.91.13.6138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lake R. A., Wotton D., Owen M. J. A 3' transcriptional enhancer regulates tissue-specific expression of the human CD2 gene. EMBO J. 1990 Oct;9(10):3129–3136. doi: 10.1002/j.1460-2075.1990.tb07510.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Larin Z., Monaco A. P., Lehrach H. Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4123–4127. doi: 10.1073/pnas.88.10.4123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McCurry K. R., Kooyman D. L., Alvarado C. G., Cotterell A. H., Martin M. J., Logan J. S., Platt J. L. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med. 1995 May;1(5):423–427. doi: 10.1038/nm0595-423. [DOI] [PubMed] [Google Scholar]
  16. McKnight R. A., Shamay A., Sankaran L., Wall R. J., Hennighausen L. Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6943–6947. doi: 10.1073/pnas.89.15.6943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mullins J. J., Mullins L. J. Transgenesis in nonmurine species. Hypertension. 1993 Oct;22(4):630–633. doi: 10.1161/01.hyp.22.4.630. [DOI] [PubMed] [Google Scholar]
  18. Mullins J. J., Peters J., Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature. 1990 Apr 5;344(6266):541–544. doi: 10.1038/344541a0. [DOI] [PubMed] [Google Scholar]
  19. Orkin S. H. Globin gene regulation and switching: circa 1990. Cell. 1990 Nov 16;63(4):665–672. doi: 10.1016/0092-8674(90)90133-y. [DOI] [PubMed] [Google Scholar]
  20. Pierce J. C., Sauer B., Sternberg N. A positive selection vector for cloning high molecular weight DNA by the bacteriophage P1 system: improved cloning efficacy. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2056–2060. doi: 10.1073/pnas.89.6.2056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rosengard A. M., Cary N. R., Langford G. A., Tucker A. W., Wallwork J., White D. J. Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. A potential approach for preventing xenograft rejection. Transplantation. 1995 May 15;59(9):1325–1333. [PubMed] [Google Scholar]
  22. Sharma A., Martin M. J., Okabe J. F., Truglio R. A., Dhanjal N. K., Logan J. S., Kumar R. An isologous porcine promoter permits high level expression of human hemoglobin in transgenic swine. Biotechnology (N Y) 1994 Jan;12(1):55–59. doi: 10.1038/nbt0194-55. [DOI] [PubMed] [Google Scholar]
  23. Shizuya H., Birren B., Kim U. J., Mancino V., Slepak T., Tachiiri Y., Simon M. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8794–8797. doi: 10.1073/pnas.89.18.8794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Solomon M. B., Pursel V. G., Paroczay E. W., Bolt D. J. Lipid composition of carcass tissue from transgenic pigs expressing a bovine growth hormone gene. J Anim Sci. 1994 May;72(5):1242–1246. doi: 10.2527/1994.7251242x. [DOI] [PubMed] [Google Scholar]
  25. Swanson M. E., Hughes T. E., Denny I. S., France D. S., Paterniti J. R., Jr, Tapparelli C., Gfeller P., Bürki K. High level expression of human apolipoprotein A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein A-I. Transgenic Res. 1992 May;1(3):142–147. doi: 10.1007/BF02528779. [DOI] [PubMed] [Google Scholar]
  26. Wheeler M. B. Development and validation of swine embryonic stem cells: a review. Reprod Fertil Dev. 1994;6(5):563–568. doi: 10.1071/rd9940563. [DOI] [PubMed] [Google Scholar]
  27. Yamanaka S., Balestra M. E., Ferrell L. D., Fan J., Arnold K. S., Taylor S., Taylor J. M., Innerarity T. L. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8483–8487. doi: 10.1073/pnas.92.18.8483. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES